Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009648300> ?p ?o ?g. }
- W2009648300 endingPage "1625" @default.
- W2009648300 startingPage "1617" @default.
- W2009648300 abstract "Sirtuins catalyze the NAD+-dependent deacetylation of target proteins, which are regulated by this reversible lysine modification. During deacetylation, the glycosidic bond of the nicotinamide ribose is cleaved to yield nicotinamide and the ribose accepts the acetyl group from substrate to produce O-acetyl-ADP-ribose (OAADPr), which exists as an ∼ 50:50 mixture of 2′ and 3′ isomers at neutral pH. Discovery of this metabolite has fueled the idea that OAADPr may play an important role in the biology associated with sirtuins, acting as a signaling molecule and/or an important substrate for downstream enzymatic processes. Evidence for OAADPr-metabolizing enzymes indicates that at least three distinct activities exist that could modulate the cellular levels of this NAD+-derived metabolite. In Saccharomyces cerevisiae, NUDIX hydrolase Ysa1 cleaves OAADPr to AMP and 2- and 3-O-acetylribose-5-phosphate, lowering the cellular levels of OAADPr. A buildup of OAADPr and ADPr has been linked to a metabolic shift that lowers endogenous reactive oxygen species and diverts glucose towards preventing oxidative damage. In vitro, the mammalian enzyme ARH3 hydrolyzes OAADPr to acetate and ADPr. A third nuclear-localized activity appears to utilize OAADPr to transfer the acetyl-group to another small molecule, whose identity remains unknown. Recent studies suggest that OAADPr may regulate gene silencing by facilitating the assembly and loading of the Sir2–4 silencing complex onto nucleosomes. In mammalian cells, the Trpm2 cation channel is gated by both OAADPr and ADP-ribose. Binding is mediated by the NUDIX homology (NudT9H) domain found within the intracellular portion of the channel. OAADPr is capable of binding the Macro domain of splice variants from histone protein MacroH2A, which is highly enriched at heterochromatic regions. With recently developed tools, the pace of new discoveries of OAADPr-dependent processes should facilitate new molecular insight into the diverse biological processes modulated by sirtuins." @default.
- W2009648300 created "2016-06-24" @default.
- W2009648300 creator A5077817714 @default.
- W2009648300 creator A5089423911 @default.
- W2009648300 date "2010-08-01" @default.
- W2009648300 modified "2023-10-03" @default.
- W2009648300 title "Function and metabolism of sirtuin metabolite O-acetyl-ADP-ribose" @default.
- W2009648300 cites W137625626 @default.
- W2009648300 cites W1516722054 @default.
- W2009648300 cites W1537218374 @default.
- W2009648300 cites W1584817945 @default.
- W2009648300 cites W1655875050 @default.
- W2009648300 cites W1875835053 @default.
- W2009648300 cites W1965112152 @default.
- W2009648300 cites W1966868505 @default.
- W2009648300 cites W1969269167 @default.
- W2009648300 cites W1971589767 @default.
- W2009648300 cites W1972789688 @default.
- W2009648300 cites W1972799522 @default.
- W2009648300 cites W1974077150 @default.
- W2009648300 cites W1974133264 @default.
- W2009648300 cites W1974890383 @default.
- W2009648300 cites W1978727518 @default.
- W2009648300 cites W1981142969 @default.
- W2009648300 cites W1985308585 @default.
- W2009648300 cites W1986320836 @default.
- W2009648300 cites W1987738803 @default.
- W2009648300 cites W1991052658 @default.
- W2009648300 cites W1991595239 @default.
- W2009648300 cites W1993113643 @default.
- W2009648300 cites W1995111407 @default.
- W2009648300 cites W1997145913 @default.
- W2009648300 cites W2000651503 @default.
- W2009648300 cites W2002028027 @default.
- W2009648300 cites W2003312750 @default.
- W2009648300 cites W2005789183 @default.
- W2009648300 cites W2007936205 @default.
- W2009648300 cites W2008483777 @default.
- W2009648300 cites W2009979784 @default.
- W2009648300 cites W2012311968 @default.
- W2009648300 cites W2017525855 @default.
- W2009648300 cites W2021309301 @default.
- W2009648300 cites W2021424485 @default.
- W2009648300 cites W2024961648 @default.
- W2009648300 cites W2025525406 @default.
- W2009648300 cites W2026898742 @default.
- W2009648300 cites W2028950501 @default.
- W2009648300 cites W2030234071 @default.
- W2009648300 cites W2034012774 @default.
- W2009648300 cites W2034467808 @default.
- W2009648300 cites W2034741173 @default.
- W2009648300 cites W2036347938 @default.
- W2009648300 cites W2036528679 @default.
- W2009648300 cites W2037104460 @default.
- W2009648300 cites W2043781485 @default.
- W2009648300 cites W2044578262 @default.
- W2009648300 cites W2044836637 @default.
- W2009648300 cites W2049094938 @default.
- W2009648300 cites W2056673958 @default.
- W2009648300 cites W2056827933 @default.
- W2009648300 cites W2064352591 @default.
- W2009648300 cites W2067775666 @default.
- W2009648300 cites W2068115362 @default.
- W2009648300 cites W2068945068 @default.
- W2009648300 cites W2069815021 @default.
- W2009648300 cites W2069974281 @default.
- W2009648300 cites W2072307255 @default.
- W2009648300 cites W2072528578 @default.
- W2009648300 cites W2073270696 @default.
- W2009648300 cites W2080422741 @default.
- W2009648300 cites W2087430129 @default.
- W2009648300 cites W2090838195 @default.
- W2009648300 cites W2091212435 @default.
- W2009648300 cites W2094807579 @default.
- W2009648300 cites W2096796564 @default.
- W2009648300 cites W2097948853 @default.
- W2009648300 cites W2098821915 @default.
- W2009648300 cites W2099377713 @default.
- W2009648300 cites W2102872728 @default.
- W2009648300 cites W2105487944 @default.
- W2009648300 cites W2106715610 @default.
- W2009648300 cites W2112275733 @default.
- W2009648300 cites W2114217399 @default.
- W2009648300 cites W2131438950 @default.
- W2009648300 cites W2135243105 @default.
- W2009648300 cites W2140455347 @default.
- W2009648300 cites W2140665078 @default.
- W2009648300 cites W2145054653 @default.
- W2009648300 cites W2148033110 @default.
- W2009648300 cites W2151027881 @default.
- W2009648300 cites W2156746537 @default.
- W2009648300 cites W2160219722 @default.
- W2009648300 cites W2161700690 @default.
- W2009648300 cites W2165512566 @default.
- W2009648300 cites W2165914529 @default.
- W2009648300 cites W2167318614 @default.
- W2009648300 cites W989386330 @default.
- W2009648300 doi "https://doi.org/10.1016/j.bbapap.2010.02.007" @default.