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• W2009649441 abstract "Oral bioavailability and pharmacokinetic behaviour of clindamycin in dogs was investigated following intravenous (IV) and oral (capsules) administration of clindamycin hydrochloride, at the dose of 11 mg/kg BW. The absorption after oral administration was fast, with a mean absorption time (MAT) of 0.87 ± 0.40 h, and bioavailability was 72.55 ± 9.86%. Total clearance (CL) of clindamycin was low, after both IV and oral administration (0.503 ± 0.095 vs. 0.458 ± 0.087 L/h/kg). Volume of distribution at steady-state (IV) was 2.48 ± 0.48 L/kg, indicating a wide distribution of clindamycin in body fluids and tissues. Elimination half-lives were similar for both routes of administration (4.37 ± 1.20 h for IV, vs. 4.37 ± 0.73 h for oral). Serum clindamycin concentrations following administration of capsules remained above the MICs of very susceptible microorganisms (0.04–0.5 μg/mL) for 12 or 10 h, respectively. Time above the mean inhibitory concentration (MIC) is considered as the index predicting the efficacy of clindamycin (T>MIC must be at least 40–50% of the dosing interval), so a once-daily oral administration of 11 mg/kg BW of clindamycin can be considered therapeutically effective. For less susceptible bacteria (with MICs of 0.5–2 μg/mL) the same dose should be given but twice daily." @default.
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• W2009649441 date "2005-11-01" @default.
• W2009649441 modified "2023-10-09" @default.
• W2009649441 title "Clindamycin bioavailability and pharmacokinetics following oral administration of clindamycin hydrochloride capsules in dogs" @default.
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• W2009649441 doi "https://doi.org/10.1016/j.tvjl.2004.06.007" @default.
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