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• W2009651971 abstract "Morphogens act as graded positional cues to control cell fate specification in many developing tissues. This concept, in which a signaling gradient regulates differential gene expression in a concentration-dependent manner, has received considerable experimental support. Nevertheless, several recent studies have challenged the straightforward model of morphogen activity. In particular, the observation that pattern formation is a dynamic process has raised questions about the influence of time on morphogen activity. Here we propose that the spatiotemporal dynamics of the cellular response to a morphogen gradient depend on a combination of temporal alterations to the morphogen gradient itself, the dynamics of its signal transduction and downstream interactions between target genes." @default.
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• W2009651971 date "2009-08-01" @default.
• W2009651971 modified "2023-09-27" @default.
• W2009651971 title "Temporal dynamics of patterning by morphogen gradients" @default.
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• W2009651971 doi "https://doi.org/10.1016/j.gde.2009.05.004" @default.
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