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• W2009654340 abstract "Helicobacter pylori is an important causative factor in gastric carcinogenesis. However, its role in extragastric gastrointestinal malignancies, such as colon neoplasia, is controversial.The aim of this study was to explore the relationship of H. pylori infection with colon neoplasia by meta-analysis of all relevant studies.Pooled estimates were obtained using fixed or random-effects models as appropriate. Heterogeneity between studies was evaluated using the Cochran Q-test, whereas the likelihood of publication bias was assessed by constructing funnel plots.Among 238 potentially relevant studies, 210 were rejected as unsuitable and 28 studies were finally eligible for meta-analysis, including a total of 33 sets of data (17 on colon cancer and 16 on colon polyps). There was evidence of heterogeneity (I=57.37%); thus, the random-effects model of meta-analysis was chosen, showing pooled odds ratio (OR) equal to 1.41 [95% confidence interval 1.24-1.60, P=0.000]. The subgroup meta-analyses showed a significant relationship between H. pylori and colon cancer as well as colon polyps [OR 1.3 (1.07-1.59), P=0.01 and OR 1.5 (1.26-1.79), P=0.000, respectively].The results of this meta-analysis showed a modest statistically significant relationship of H. pylori infection with both colon cancer and polyps." @default.
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• W2009654340 date "2013-11-01" @default.
• W2009654340 modified "2023-10-07" @default.
• W2009654340 title "The relationship of Helicobacter pylori infection and colon neoplasia, on the basis of meta-analysis" @default.
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• W2009654340 doi "https://doi.org/10.1097/meg.0b013e328363d3cd" @default.
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