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- W2009658003 abstract "Injection into the superior colliculus of anaesthetised rats of the nitric oxide (NO) synthase inhibitor Nω-nitro-l-arginine methyl ester (l-NAME; 1 μmol), but not its inactive enantiomer Nω-nitro-d-arginine methyl ester (d-NAME; 1 μmol), significantly (P<0.01) increased the mean arterial blood pressure. Injection to the superior colliculus of l-arginine (l-Arg; 1 μmol), the substrate for NO synthase, significantly (P<0.01) lessened the pressor effect of l-NAME, while d-arginine (d-Arg; 1 μmol) did not affect it. l-Arg (7.5 μmol), but not d-Arg (7.5 μmol) administered at the peak of the pressor response to l-NAME (1 μmol) also partially reversed this pressor response (P<0.05). These data would suggest that endogenously produced NO acts within the superior colliculus to modulate the arterial blood pressure." @default.
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- W2009658003 title "Regulation of blood pressure by l-arginine-nitric oxide pathway within the superior colliculus of rats" @default.
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- W2009658003 doi "https://doi.org/10.1016/s0014-2999(97)83029-4" @default.
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