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- W2009675441 abstract "In this study, we used in vitro electrophysiology along with immunohistochemistry and molecular techniques to study the subiculum—a limbic structure that gates the information flow from and to the hippocampus—in pilocarpine-treated epileptic rats. Comparative data were obtained from age-matched nonepileptic controls (NEC). Subicular neurons in hippocampal-entorhinal cortex (EC) slices of epileptic rats were: (i) hyperexcitable when activated by CA1 or EC inputs; and (ii) generated spontaneous postsynaptic potentials at higher frequencies than NEC cells. Analysis of pharmacologically isolated, GABAA receptor-mediated inhibitory postsynaptic potentials revealed more positive reversal potentials in epileptic tissue (−67.8 ± 6.3 mV, n = 16 vs. −74.8 ± 3.6 mV in NEC, n = 13; P < 0.001) combined with a reduction in peak conductance (17.6 ± 11.3 nS vs. 41.1 ± 26.7 nS in NEC; P < 0.003). These electrophysiological data correlated in the epileptic subiculum with (i) reduced levels of mRNA expression and immunoreactivity of the neuron-specific potassium-chloride cotransporter 2; (ii) decreased number of parvalbumin-positive cells; and (iii) increased synaptophysin (a putative marker of sprouting) immunoreactivity. These findings identify an increase in network excitability within the subiculum of pilocarpine-treated, epileptic rats and point at a reduction in inhibition as an underlying mechanism. © 2006 Wiley-Liss, Inc." @default.
- W2009675441 created "2016-06-24" @default.
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- W2009675441 date "2006-01-01" @default.
- W2009675441 modified "2023-10-12" @default.
- W2009675441 title "Subiculum network excitability is increased in a rodent model of temporal lobe epilepsy" @default.
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- W2009675441 doi "https://doi.org/10.1002/hipo.20215" @default.
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