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• W2009679871 abstract "Adenosine present in human brain glioma extracellular spaces is a marker of astrocyte purine metabolism. In this study, we evaluated adenosine levels in the extracellular fluid of 21 human gliomas of high-grade malignancy using brain microdialysis techniques coupled to high-performance liquid chromatography. The adenosine concentration (mean+/-SEM) within the control tissue was 2.99+/-0.37 microM and in the tumour tissue 1.56+/-0.46 microM. The reduction was statistically significant. It is concluded that the adenosine concentrations reached in the tumour tissue are sufficient to stimulate all adenosine receptor subtypes, suppress local anti-tumour immune responses and affect glial and endothelial cell proliferation." @default.
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• W2009679871 date "2003-07-01" @default.
• W2009679871 modified "2023-10-09" @default.
• W2009679871 title "Adenosine extracellular levels in human brain gliomas: an intraoperative microdialysis study" @default.
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• W2009679871 doi "https://doi.org/10.1016/s0304-3940(03)00596-2" @default.
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