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- W2009681618 abstract "Hereditary breast carcinomas that are attributable to BRCA1/2 mutations have their own morphological and immunohistochemical characteristics. BRCA1-associated carcinomas are poorly differentiated infiltrating ductal carcinomas that frequently show morphological features of typical or atypical medullary carcinoma. BRCA2-associated breast carcinomas tend to be of higher grade than sporadic age-matched controls. BRCA1tumors have been found to be more frequently estrogen receptor- and progesterone receptor-negative, and p53-positive than are age-matched controls, whereas these differences are not usually found in BRCA2-associated tumors. In addition, BRCA1- and BRCA2-associated breast carcinomas show a low frequency of HER2 expression. Most BRCA1 breast carcinomas are characterized by the expression of basal (myoepithelial) markers, such as cytokeratin 5/6 and or P-cadherin. These features could be used to distinguish patients who are likely to carry a BRCA1 or BRCA2 germline mutation, thus indicating which gene should be screened for first in families with a high incidence of breast and ovarian cancer." @default.
- W2009681618 created "2016-06-24" @default.
- W2009681618 creator A5004714870 @default.
- W2009681618 creator A5052211470 @default.
- W2009681618 creator A5090159813 @default.
- W2009681618 date "2006-07-01" @default.
- W2009681618 modified "2023-10-16" @default.
- W2009681618 title "Histopathology of BRCA1- and BRCA2-associated breast cancer" @default.
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