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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009686935> ?p ?o ?g. }

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• W2009686935 abstract "This note demonstrates a novel mode of rhythmic drug delivery, which is independent of external modulation or physiological stimulation. Rhythmic behavior is attributed to negative, nonlinear feedback between the swelling state of a hydrogel membrane and the enzymatic conversion of glucose to hydrogen ion. The system pulsates in the presence of a constant level of glucose, thus distinguishing it from insulin delivery devices that respond to changes in glucose concentration. As an example, gonadotropin-releasing hormone (GnRH) was released in short, repetitive pulses over 1 week." @default.
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• W2009686935 date "2002-05-01" @default.
• W2009686935 modified "2023-09-26" @default.
• W2009686935 title "New mode of drug delivery: long term autonomous rhythmic hormone release across a hydrogel membrane" @default.
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• W2009686935 doi "https://doi.org/10.1016/s0168-3659(02)00043-3" @default.
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