Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009689679> ?p ?o ?g. }
- W2009689679 endingPage "6105" @default.
- W2009689679 startingPage "6090" @default.
- W2009689679 abstract "PAX2 is one of nine PAX genes that regulate tissue development and cellular differentiation in embryos. However, the functional role of PAX2 in ovarian cancer is not known. Twenty-six ovarian cancer cell lines with different histology origins were screened for PAX2 expression. Two ovarian cancer cell lines: RMUGL (mucinous) and TOV21G (clear cell), with high PAX2 expression were chosen for further study. Knockdown PAX2 expression in these cell lines was achieved by lentiviral shRNAs targeting the PAX2 gene. PAX2 stable knockdown cells were characterized for cell proliferation, migration, apoptosis, protein profiles, and gene expression profiles. The result indicated that these stable PAX2 knockdown cells had reduced cell proliferation and migration. Microarray analysis indicated that several genes involved in growth inhibition and motility, such as G0S2, GREM1, and WFDC1, were up-regulated in PAX2 knockdown cells. On the other hand, over-expressing PAX2 in PAX2-negative ovarian cell lines suppressed their cell proliferation. In summary, PAX2 could have both oncogenic and tumor suppression functions, which might depend on the genetic content of the ovarian cancer cells. Further investigation of PAX2 in tumor suppression and mortality is warranty." @default.
- W2009689679 created "2016-06-24" @default.
- W2009689679 creator A5009451090 @default.
- W2009689679 creator A5018745283 @default.
- W2009689679 creator A5019407817 @default.
- W2009689679 creator A5035525279 @default.
- W2009689679 creator A5042887409 @default.
- W2009689679 creator A5060787282 @default.
- W2009689679 creator A5066564517 @default.
- W2009689679 creator A5070496227 @default.
- W2009689679 creator A5074272701 @default.
- W2009689679 creator A5085045114 @default.
- W2009689679 date "2013-03-15" @default.
- W2009689679 modified "2023-09-25" @default.
- W2009689679 title "PAX2 Expression in Ovarian Cancer" @default.
- W2009689679 cites W1554979174 @default.
- W2009689679 cites W1969381388 @default.
- W2009689679 cites W1982000572 @default.
- W2009689679 cites W1988175987 @default.
- W2009689679 cites W1990615996 @default.
- W2009689679 cites W1992292349 @default.
- W2009689679 cites W1992781718 @default.
- W2009689679 cites W1993902938 @default.
- W2009689679 cites W2004354462 @default.
- W2009689679 cites W2012896828 @default.
- W2009689679 cites W2013520280 @default.
- W2009689679 cites W2014739095 @default.
- W2009689679 cites W2017151634 @default.
- W2009689679 cites W2023886604 @default.
- W2009689679 cites W2033771065 @default.
- W2009689679 cites W2034852369 @default.
- W2009689679 cites W2042744803 @default.
- W2009689679 cites W2044384686 @default.
- W2009689679 cites W2051469465 @default.
- W2009689679 cites W2059226469 @default.
- W2009689679 cites W2064320611 @default.
- W2009689679 cites W2068597923 @default.
- W2009689679 cites W2070369494 @default.
- W2009689679 cites W2071991599 @default.
- W2009689679 cites W2078654947 @default.
- W2009689679 cites W2080068472 @default.
- W2009689679 cites W2092933936 @default.
- W2009689679 cites W2102058489 @default.
- W2009689679 cites W2102168616 @default.
- W2009689679 cites W2108210649 @default.
- W2009689679 cites W2117419186 @default.
- W2009689679 cites W2118763131 @default.
- W2009689679 cites W2125646794 @default.
- W2009689679 cites W2131369455 @default.
- W2009689679 cites W2135546199 @default.
- W2009689679 cites W2140917992 @default.
- W2009689679 cites W2148651857 @default.
- W2009689679 cites W2151445759 @default.
- W2009689679 cites W2152261493 @default.
- W2009689679 cites W2154140079 @default.
- W2009689679 cites W2158605807 @default.
- W2009689679 cites W2158849185 @default.
- W2009689679 doi "https://doi.org/10.3390/ijms14036090" @default.
- W2009689679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3634442" @default.
- W2009689679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23502471" @default.
- W2009689679 hasPublicationYear "2013" @default.
- W2009689679 type Work @default.
- W2009689679 sameAs 2009689679 @default.
- W2009689679 citedByCount "25" @default.
- W2009689679 countsByYear W20096896792013 @default.
- W2009689679 countsByYear W20096896792014 @default.
- W2009689679 countsByYear W20096896792015 @default.
- W2009689679 countsByYear W20096896792016 @default.
- W2009689679 countsByYear W20096896792017 @default.
- W2009689679 countsByYear W20096896792018 @default.
- W2009689679 countsByYear W20096896792019 @default.
- W2009689679 countsByYear W20096896792020 @default.
- W2009689679 countsByYear W20096896792021 @default.
- W2009689679 countsByYear W20096896792022 @default.
- W2009689679 countsByYear W20096896792023 @default.
- W2009689679 crossrefType "journal-article" @default.
- W2009689679 hasAuthorship W2009689679A5009451090 @default.
- W2009689679 hasAuthorship W2009689679A5018745283 @default.
- W2009689679 hasAuthorship W2009689679A5019407817 @default.
- W2009689679 hasAuthorship W2009689679A5035525279 @default.
- W2009689679 hasAuthorship W2009689679A5042887409 @default.
- W2009689679 hasAuthorship W2009689679A5060787282 @default.
- W2009689679 hasAuthorship W2009689679A5066564517 @default.
- W2009689679 hasAuthorship W2009689679A5070496227 @default.
- W2009689679 hasAuthorship W2009689679A5074272701 @default.
- W2009689679 hasAuthorship W2009689679A5085045114 @default.
- W2009689679 hasBestOaLocation W20096896791 @default.
- W2009689679 hasConcept C104317684 @default.
- W2009689679 hasConcept C121608353 @default.
- W2009689679 hasConcept C1491633281 @default.
- W2009689679 hasConcept C150194340 @default.
- W2009689679 hasConcept C173396325 @default.
- W2009689679 hasConcept C2780427987 @default.
- W2009689679 hasConcept C502942594 @default.
- W2009689679 hasConcept C54355233 @default.
- W2009689679 hasConcept C62112901 @default.
- W2009689679 hasConcept C81885089 @default.
- W2009689679 hasConcept C8415881 @default.