FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009694511> ?p ?o ?g. }

• W2009694511 endingPage "762" @default.
• W2009694511 startingPage "759" @default.
• W2009694511 abstract "In Brief Dopamine is a thermoregulatory neurotransmitter that provokes hypothermia when injected in or near the hypothalamus. Doxapram stimulates release of dopamine from carotid bodies, but is known to have central effects that are probably, at least in part, similarly mediated. We thus tested the hypothesis that doxapram produces a substantial, dose-dependent reduction in the shivering threshold in rabbits. Twenty-four rabbits, anesthetized with isoflurane, were randomly assigned to 1) saline (control), 2) 0.25 mg · kg−1 · h−1 doxapram, or 3) 0.50 mg · kg−1 · h−1 doxapram. These doses are within the recommended range for humans. Body temperature was reduced at a rate of 2° to 3°C/h by perfusing water at 10°C through a U-shaped thermode positioned in the colon. Core temperatures were recorded from the distal esophagus. A blinded observer evaluated shivering. Core temperature at the onset of shivering defined the threshold. Data were analyzed with a one-way analysis of variance; P < 0.05 was considered statistically significant. Hemodynamic and respiratory responses were comparable in the groups. The control rabbits shivered at 36.3° ± 0.3°C, those given 0.25 mg · kg−1 · h−1 doxapram shivered at 34.8° ± 0.5°C, and those given 0.50 mg · kg−1 · h−1 shivered at 33.7° ± 0.6°C. All the shivering thresholds significantly (P < 0.001) differed from one another. The magnitude of this inhibition, if similar in humans, would be clinically important. IMPLICATIONS: Doxapram produced a substantial and dose-dependent reduction in the shivering threshold. The magnitude of this inhibition, if similar in humans, would be clinically important. Clinical studies are thus indicated to determine whether the drug might help defeat thermoregulatory defenses during induction of therapeutic hypothermia." @default.
• W2009694511 created "2016-06-24" @default.
• W2009694511 creator A5019474415 @default.
• W2009694511 creator A5028329455 @default.
• W2009694511 creator A5040963836 @default.
• W2009694511 creator A5042996287 @default.
• W2009694511 creator A5054953841 @default.
• W2009694511 creator A5062258827 @default.
• W2009694511 creator A5063380744 @default.
• W2009694511 date "2003-09-01" @default.
• W2009694511 modified "2023-09-26" @default.
• W2009694511 title "Doxapram Produces a Dose-Dependent Reduction in the Shivering Threshold in Rabbits" @default.
• W2009694511 cites W124958622 @default.
• W2009694511 cites W133345151 @default.
• W2009694511 cites W1488770136 @default.
• W2009694511 cites W1963924800 @default.
• W2009694511 cites W1965748510 @default.
• W2009694511 cites W1967437320 @default.
• W2009694511 cites W1969332945 @default.
• W2009694511 cites W1973124198 @default.
• W2009694511 cites W1973747052 @default.
• W2009694511 cites W1975303253 @default.
• W2009694511 cites W1977562071 @default.
• W2009694511 cites W1979235678 @default.
• W2009694511 cites W1985697512 @default.
• W2009694511 cites W1988842220 @default.
• W2009694511 cites W1997267385 @default.
• W2009694511 cites W2003431622 @default.
• W2009694511 cites W2004707621 @default.
• W2009694511 cites W2009500406 @default.
• W2009694511 cites W2020293841 @default.
• W2009694511 cites W2044558604 @default.
• W2009694511 cites W2046923691 @default.
• W2009694511 cites W2052377203 @default.
• W2009694511 cites W2063766620 @default.
• W2009694511 cites W2066573197 @default.
• W2009694511 cites W2076110258 @default.
• W2009694511 cites W2103550628 @default.
• W2009694511 cites W2110193433 @default.
• W2009694511 cites W2113887265 @default.
• W2009694511 cites W2113939477 @default.
• W2009694511 cites W2130918836 @default.
• W2009694511 cites W2152870933 @default.
• W2009694511 cites W2155102101 @default.
• W2009694511 cites W2160252183 @default.
• W2009694511 cites W2333052542 @default.
• W2009694511 cites W4254452317 @default.
• W2009694511 cites W4577952 @default.
• W2009694511 doi "https://doi.org/10.1213/01.ane.0000076062.62939.91" @default.
• W2009694511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12933397" @default.
• W2009694511 hasPublicationYear "2003" @default.
• W2009694511 type Work @default.
• W2009694511 sameAs 2009694511 @default.
• W2009694511 citedByCount "7" @default.
• W2009694511 countsByYear W20096945112014 @default.
• W2009694511 countsByYear W20096945112022 @default.
• W2009694511 crossrefType "journal-article" @default.
• W2009694511 hasAuthorship W2009694511A5019474415 @default.
• W2009694511 hasAuthorship W2009694511A5028329455 @default.
• W2009694511 hasAuthorship W2009694511A5040963836 @default.
• W2009694511 hasAuthorship W2009694511A5042996287 @default.
• W2009694511 hasAuthorship W2009694511A5054953841 @default.
• W2009694511 hasAuthorship W2009694511A5062258827 @default.
• W2009694511 hasAuthorship W2009694511A5063380744 @default.
• W2009694511 hasBestOaLocation W20096945111 @default.
• W2009694511 hasConcept C100564792 @default.
• W2009694511 hasConcept C126322002 @default.
• W2009694511 hasConcept C2776976630 @default.
• W2009694511 hasConcept C2777390192 @default.
• W2009694511 hasConcept C2781258859 @default.
• W2009694511 hasConcept C42219234 @default.
• W2009694511 hasConcept C71924100 @default.
• W2009694511 hasConceptScore W2009694511C100564792 @default.
• W2009694511 hasConceptScore W2009694511C126322002 @default.
• W2009694511 hasConceptScore W2009694511C2776976630 @default.
• W2009694511 hasConceptScore W2009694511C2777390192 @default.
• W2009694511 hasConceptScore W2009694511C2781258859 @default.
• W2009694511 hasConceptScore W2009694511C42219234 @default.
• W2009694511 hasConceptScore W2009694511C71924100 @default.
• W2009694511 hasLocation W20096945111 @default.
• W2009694511 hasOpenAccess W2009694511 @default.
• W2009694511 hasPrimaryLocation W20096945111 @default.
• W2009694511 hasRelatedWork W1898868703 @default.
• W2009694511 hasRelatedWork W1979235678 @default.
• W2009694511 hasRelatedWork W2000415543 @default.
• W2009694511 hasRelatedWork W2045965132 @default.
• W2009694511 hasRelatedWork W2089928056 @default.
• W2009694511 hasRelatedWork W2102440663 @default.
• W2009694511 hasRelatedWork W2113939477 @default.
• W2009694511 hasRelatedWork W2162937581 @default.
• W2009694511 hasRelatedWork W2225678948 @default.
• W2009694511 hasRelatedWork W2413622215 @default.
• W2009694511 isParatext "false" @default.
• W2009694511 isRetracted "false" @default.
• W2009694511 magId "2009694511" @default.
• W2009694511 workType "article" @default.