Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009698541> ?p ?o ?g. }
- W2009698541 endingPage "239" @default.
- W2009698541 startingPage "235" @default.
- W2009698541 abstract "By sequentially pushing micro-beads towards and away from a sensing surface, we show that ultrasonic radiation forces can be used to enhance the interaction between a functionalised glass surface and polystyrene micro-beads, and identify those that bind to the surface by illuminating bound beads using an evanescent field generated by guided light. The movement towards and immobilisation of streptavidin coated beads onto a biotin functionalised waveguide surface is achieved by using a quarter-wavelength mode pushing beads onto the surface, while the removal of non-specifically bound beads uses a second quarter-wavelength mode which exhibits a kinetic energy maximum at the boundary between the carrier layer and fluid, drawing beads towards this surface. This has been achieved using a multi-modal acoustic device which exhibits both of these quarter-wavelength resonances. Both 1-D acoustic modelling and finite element analysis has been used to design this device and to investigate the spatial uniformity of the field. We demonstrate experimentally that 90% of specifically bound beads remain attached after applying ultrasound, with 80% of non-specifically bound control beads being successfully removed acoustically. This approach overcomes problems associated with lengthy sedimentation processes used for bead-based bioassays and surface (electrostatic) forces, which delay or prevent immobilisation. We explain the potential of this technique in the development of DNA and protein assays in terms of detection speed and multiplexing." @default.
- W2009698541 created "2016-06-24" @default.
- W2009698541 creator A5022955040 @default.
- W2009698541 creator A5033476226 @default.
- W2009698541 creator A5043244656 @default.
- W2009698541 creator A5048008441 @default.
- W2009698541 creator A5048601142 @default.
- W2009698541 creator A5054262616 @default.
- W2009698541 creator A5058341036 @default.
- W2009698541 creator A5069345658 @default.
- W2009698541 creator A5076494194 @default.
- W2009698541 date "2010-02-01" @default.
- W2009698541 modified "2023-09-27" @default.
- W2009698541 title "Multi-modal particle manipulator to enhance bead-based bioassays" @default.
- W2009698541 cites W1987483019 @default.
- W2009698541 cites W2027610384 @default.
- W2009698541 cites W2040171948 @default.
- W2009698541 cites W2071172826 @default.
- W2009698541 cites W2083885041 @default.
- W2009698541 cites W2083974946 @default.
- W2009698541 cites W2155018859 @default.
- W2009698541 cites W2161387760 @default.
- W2009698541 cites W4300178594 @default.
- W2009698541 doi "https://doi.org/10.1016/j.ultras.2009.09.025" @default.
- W2009698541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19889436" @default.
- W2009698541 hasPublicationYear "2010" @default.
- W2009698541 type Work @default.
- W2009698541 sameAs 2009698541 @default.
- W2009698541 citedByCount "10" @default.
- W2009698541 countsByYear W20096985412012 @default.
- W2009698541 countsByYear W20096985412013 @default.
- W2009698541 countsByYear W20096985412014 @default.
- W2009698541 countsByYear W20096985412015 @default.
- W2009698541 countsByYear W20096985412017 @default.
- W2009698541 countsByYear W20096985412018 @default.
- W2009698541 crossrefType "journal-article" @default.
- W2009698541 hasAuthorship W2009698541A5022955040 @default.
- W2009698541 hasAuthorship W2009698541A5033476226 @default.
- W2009698541 hasAuthorship W2009698541A5043244656 @default.
- W2009698541 hasAuthorship W2009698541A5048008441 @default.
- W2009698541 hasAuthorship W2009698541A5048601142 @default.
- W2009698541 hasAuthorship W2009698541A5054262616 @default.
- W2009698541 hasAuthorship W2009698541A5058341036 @default.
- W2009698541 hasAuthorship W2009698541A5069345658 @default.
- W2009698541 hasAuthorship W2009698541A5076494194 @default.
- W2009698541 hasBestOaLocation W20096985412 @default.
- W2009698541 hasConcept C109386097 @default.
- W2009698541 hasConcept C111368507 @default.
- W2009698541 hasConcept C120665830 @default.
- W2009698541 hasConcept C121332964 @default.
- W2009698541 hasConcept C127313418 @default.
- W2009698541 hasConcept C135628077 @default.
- W2009698541 hasConcept C159985019 @default.
- W2009698541 hasConcept C171250308 @default.
- W2009698541 hasConcept C185592680 @default.
- W2009698541 hasConcept C192562407 @default.
- W2009698541 hasConcept C2776190903 @default.
- W2009698541 hasConcept C2777922577 @default.
- W2009698541 hasConcept C2778204606 @default.
- W2009698541 hasConcept C2778517922 @default.
- W2009698541 hasConcept C49040817 @default.
- W2009698541 hasConcept C521977710 @default.
- W2009698541 hasConcept C55493867 @default.
- W2009698541 hasConcept C6260449 @default.
- W2009698541 hasConcept C97355855 @default.
- W2009698541 hasConceptScore W2009698541C109386097 @default.
- W2009698541 hasConceptScore W2009698541C111368507 @default.
- W2009698541 hasConceptScore W2009698541C120665830 @default.
- W2009698541 hasConceptScore W2009698541C121332964 @default.
- W2009698541 hasConceptScore W2009698541C127313418 @default.
- W2009698541 hasConceptScore W2009698541C135628077 @default.
- W2009698541 hasConceptScore W2009698541C159985019 @default.
- W2009698541 hasConceptScore W2009698541C171250308 @default.
- W2009698541 hasConceptScore W2009698541C185592680 @default.
- W2009698541 hasConceptScore W2009698541C192562407 @default.
- W2009698541 hasConceptScore W2009698541C2776190903 @default.
- W2009698541 hasConceptScore W2009698541C2777922577 @default.
- W2009698541 hasConceptScore W2009698541C2778204606 @default.
- W2009698541 hasConceptScore W2009698541C2778517922 @default.
- W2009698541 hasConceptScore W2009698541C49040817 @default.
- W2009698541 hasConceptScore W2009698541C521977710 @default.
- W2009698541 hasConceptScore W2009698541C55493867 @default.
- W2009698541 hasConceptScore W2009698541C6260449 @default.
- W2009698541 hasConceptScore W2009698541C97355855 @default.
- W2009698541 hasIssue "2" @default.
- W2009698541 hasLocation W20096985411 @default.
- W2009698541 hasLocation W20096985412 @default.
- W2009698541 hasLocation W20096985413 @default.
- W2009698541 hasLocation W20096985414 @default.
- W2009698541 hasOpenAccess W2009698541 @default.
- W2009698541 hasPrimaryLocation W20096985411 @default.
- W2009698541 hasRelatedWork W2018236531 @default.
- W2009698541 hasRelatedWork W2064860641 @default.
- W2009698541 hasRelatedWork W2078187821 @default.
- W2009698541 hasRelatedWork W2165340258 @default.
- W2009698541 hasRelatedWork W2170520389 @default.
- W2009698541 hasRelatedWork W2330787876 @default.
- W2009698541 hasRelatedWork W2533770197 @default.