Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009698911> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2009698911 abstract "Induction of tolerance to an allogeneic graft without the need for nonspecific immunosuppression is a major goal of transplantation therapy. We have shown that treatment with molecularly engineered, allochimeric [alpha(1h)(1/u)]-RT1.Aa class I MHC antigens bearing donor-type Wistar-Furth (WF, RT1.A(u)) or Lewis (LEW, RT1A(1)) amino acid substitutions for host-type ACI (RTI.A(a)) sequences in the alpha(1)-helical region induces donor-specific tolerance to cardiac allografts in rat recipients. The mechanisms involved in the establishment and maintenance of specific allograft tolerance are still not fully understood. It is now clear that acquisition of transplantation tolerance is an active, highly regulated, multistep process. According to the pool size model of allograft tolerance, the allograft outcome, rejection, or tolerance often depend on the balance between cytopathic and regulatory T cells (T-regs). This study examined mechanisms of chronic rejection (CR) development on a model of cardiac transplant tolerance after adoptive transfer of T-regs followed by allochimeric therapy. Generation of T-regs was demonstrated in vitro by MLR coculture and confirmed by adoptive transfer of T cells from primary recipients to secondary hosts. To confirm the true nature of regulatory cells, we performed a second transfer into tertiary recipients. Unlike T-regs from tolerant hosts, T cells from naive rats did not prolong graft survival. Histological evaluation of T-regs-transfected groups showed absence of visible CR. In contrast, T-regs generated in recipients after high-dose cyclosporine treatment failed to inhibit CR in transferred singeneic recipients. Allochimeric therapy triggers generation of unique regulatory lymphocytes that mitigate development of chronic rejection through regulation of anti-inflammatory mechanisms and down-regulation of alloantibody response." @default.
- W2009698911 created "2016-06-24" @default.
- W2009698911 creator A5003676197 @default.
- W2009698911 creator A5016218484 @default.
- W2009698911 creator A5024924319 @default.
- W2009698911 creator A5034716774 @default.
- W2009698911 creator A5062372581 @default.
- W2009698911 creator A5065649640 @default.
- W2009698911 creator A5075909338 @default.
- W2009698911 creator A5084206420 @default.
- W2009698911 date "2005-01-01" @default.
- W2009698911 modified "2023-10-18" @default.
- W2009698911 title "Allochimeric therapy induces unique regulatory T cells that mitigate chronic rejection" @default.
- W2009698911 cites W2018069506 @default.
- W2009698911 cites W2019494797 @default.
- W2009698911 doi "https://doi.org/10.1016/j.transproceed.2004.12.061" @default.
- W2009698911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15808538" @default.
- W2009698911 hasPublicationYear "2005" @default.
- W2009698911 type Work @default.
- W2009698911 sameAs 2009698911 @default.
- W2009698911 citedByCount "2" @default.
- W2009698911 crossrefType "journal-article" @default.
- W2009698911 hasAuthorship W2009698911A5003676197 @default.
- W2009698911 hasAuthorship W2009698911A5016218484 @default.
- W2009698911 hasAuthorship W2009698911A5024924319 @default.
- W2009698911 hasAuthorship W2009698911A5034716774 @default.
- W2009698911 hasAuthorship W2009698911A5062372581 @default.
- W2009698911 hasAuthorship W2009698911A5065649640 @default.
- W2009698911 hasAuthorship W2009698911A5075909338 @default.
- W2009698911 hasAuthorship W2009698911A5084206420 @default.
- W2009698911 hasConcept C126322002 @default.
- W2009698911 hasConcept C147483822 @default.
- W2009698911 hasConcept C202751555 @default.
- W2009698911 hasConcept C203014093 @default.
- W2009698911 hasConcept C207936829 @default.
- W2009698911 hasConcept C2776090121 @default.
- W2009698911 hasConcept C2777702733 @default.
- W2009698911 hasConcept C2780252810 @default.
- W2009698911 hasConcept C2911091166 @default.
- W2009698911 hasConcept C55493867 @default.
- W2009698911 hasConcept C71924100 @default.
- W2009698911 hasConcept C86803240 @default.
- W2009698911 hasConcept C8891405 @default.
- W2009698911 hasConcept C90375314 @default.
- W2009698911 hasConceptScore W2009698911C126322002 @default.
- W2009698911 hasConceptScore W2009698911C147483822 @default.
- W2009698911 hasConceptScore W2009698911C202751555 @default.
- W2009698911 hasConceptScore W2009698911C203014093 @default.
- W2009698911 hasConceptScore W2009698911C207936829 @default.
- W2009698911 hasConceptScore W2009698911C2776090121 @default.
- W2009698911 hasConceptScore W2009698911C2777702733 @default.
- W2009698911 hasConceptScore W2009698911C2780252810 @default.
- W2009698911 hasConceptScore W2009698911C2911091166 @default.
- W2009698911 hasConceptScore W2009698911C55493867 @default.
- W2009698911 hasConceptScore W2009698911C71924100 @default.
- W2009698911 hasConceptScore W2009698911C86803240 @default.
- W2009698911 hasConceptScore W2009698911C8891405 @default.
- W2009698911 hasConceptScore W2009698911C90375314 @default.
- W2009698911 hasLocation W20096989111 @default.
- W2009698911 hasLocation W20096989112 @default.
- W2009698911 hasOpenAccess W2009698911 @default.
- W2009698911 hasPrimaryLocation W20096989111 @default.
- W2009698911 hasRelatedWork W1217682272 @default.
- W2009698911 hasRelatedWork W1769978316 @default.
- W2009698911 hasRelatedWork W2026564383 @default.
- W2009698911 hasRelatedWork W2136175148 @default.
- W2009698911 hasRelatedWork W2141965224 @default.
- W2009698911 hasRelatedWork W2251340927 @default.
- W2009698911 hasRelatedWork W2402149178 @default.
- W2009698911 hasRelatedWork W2414608944 @default.
- W2009698911 hasRelatedWork W2462996121 @default.
- W2009698911 hasRelatedWork W70067030 @default.
- W2009698911 isParatext "false" @default.
- W2009698911 isRetracted "false" @default.
- W2009698911 magId "2009698911" @default.
- W2009698911 workType "article" @default.