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- W2009698946 abstract "1. The effects of norepinephrine, epinephrine and clonidine on neurogenic cholinergic contraction were examined in the presence of a beta-adrenoceptor blocking agent, carteolol (5 × 10−6M), in the isolated intestinal bulb of the carp. 2. Norepinephrine, epinephrine (10−9 −10−6 M) and clonidine (10−8 −10−5 M) inhibited the contraction induced by low frequency (2 or 5 Hz) transmural stimulation (TMS) without inhibiting the contraction induced by acetylcholine (ACh, 6 × 10−8 −4 × 10−7 M). Methoxamine (10−4M) and phenylephrine (10−4M) showed no such inhibitory effect on the TMS-induced contraction. 3. The inhibitory effects of catecholamines and clonidine were decreased by phentolamine (5.4 × 10−6M) and yohimbine (10−7 −10−6 M) but not by prazosin (7 × 10−7 −10−6 M). 4. Nicotine (10−6 −10−4 M) and serotonin (3 × 10−8 −3 × 10−6 M) caused contraction of the intestinal bulb indirectly by releasing endogenous ACh. This contraction was inhibited by norepinephrine, epinephrine and clonidine in a concentration-dependent manner. 5. The present results suggest that catecholamines and clonidine inhibit cholinergic transmission via the activation of a presynaptic alpha-adrenoceptor (presumably of alpha-2 type) located on the cholinergic nerve terminals innervating the smooth muscle of the intestinal bulb of the carp." @default.
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- W2009698946 date "1986-01-01" @default.
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- W2009698946 title "Presynaptic alpha-adrenoceptor mediated inhibition of the neurogenic cholinergic contraction in the isolated intestinal bulb of the carp (Cyprinus carpio)" @default.
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- W2009698946 doi "https://doi.org/10.1016/0742-8413(86)90122-2" @default.
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