Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009703085> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2009703085 abstract "The objective of this study was to evaluate the activity and toxicity of combined cisplatin, etoposide, and gemcitabine (PEG) and combined cisplatin plus gemcitabine (PG) in previously untreated patients with extensive-stage and poor-prognosis limited-stage small-cell lung carcinoma.One hundred forty patients (70 patients in two arms) were randomized to receive either cisplatin 70 mg/m2 on Day 1, etoposide 50 mg/m2 on Days 1-3, and gemcitabine 1000 mg/m2 on Days 1 and 8 or cisplatin 70 mg/m2 on Day 1 plus gemcitabine 1250 mg/m2 on Days 1 and 8. Both regimens were recycled every 21 days.In total, 626 cycles were delivered (303 cycles of PEG and 323 cycles of PG), with a median of 4 cycles per patient in both arms. The objective response rate was 63% (95% confidence interval [95%CI], 49-71%) for PEG and 57% (95%CI, 43-67%) for PG, with the suggestion of a higher complete response rate in the PEG arm (18.6% and 4.3%, respectively). A similar time to disease progression (6 months in the PEG arm and 7 months in the PG arm) and a similar median survival (9.5 months in the PEG arm and 10 months in the PG arm) were observed in both arms. The PEG regimen was associated with more severe hematologic toxicity in terms of neutropenia, febrile neutropenia, and a higher rate of treatment delays and dose reductions, whereas nonhematologic toxicities did not differ between the two arms.According to the results of this Phase II randomized trial, the PEG regimen produced a higher complete response rate but more toxicity compared with the PG regimen in patients with extensive-stage or poor-prognosis, limited-stage small cell lung carcinoma." @default.
- W2009703085 created "2016-06-24" @default.
- W2009703085 creator A5003664573 @default.
- W2009703085 creator A5020421670 @default.
- W2009703085 creator A5020736353 @default.
- W2009703085 creator A5032066228 @default.
- W2009703085 creator A5044602168 @default.
- W2009703085 creator A5045384053 @default.
- W2009703085 creator A5048720703 @default.
- W2009703085 creator A5049781283 @default.
- W2009703085 creator A5061179981 @default.
- W2009703085 creator A5084773667 @default.
- W2009703085 date "2005-01-07" @default.
- W2009703085 modified "2023-10-16" @default.
- W2009703085 title "A multicenter, randomized, Phase II study of cisplatin, etoposide, and gemcitabine or cisplatin plus gemcitabine as first-line treatment in patients with poor-prognosis small cell lung carcinoma" @default.
- W2009703085 cites W2000159952 @default.
- W2009703085 cites W2007526924 @default.
- W2009703085 cites W2029409133 @default.
- W2009703085 cites W2047930003 @default.
- W2009703085 cites W2060171352 @default.
- W2009703085 cites W2073683299 @default.
- W2009703085 cites W2086905049 @default.
- W2009703085 cites W2105847144 @default.
- W2009703085 cites W2111218876 @default.
- W2009703085 cites W2127776375 @default.
- W2009703085 cites W2128076724 @default.
- W2009703085 cites W2130164889 @default.
- W2009703085 cites W2133495180 @default.
- W2009703085 cites W2139184637 @default.
- W2009703085 cites W2167805334 @default.
- W2009703085 cites W2168980896 @default.
- W2009703085 cites W2173643829 @default.
- W2009703085 cites W4293241248 @default.
- W2009703085 cites W4434567 @default.
- W2009703085 doi "https://doi.org/10.1002/cncr.20859" @default.
- W2009703085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15641037" @default.
- W2009703085 hasPublicationYear "2005" @default.
- W2009703085 type Work @default.
- W2009703085 sameAs 2009703085 @default.
- W2009703085 citedByCount "10" @default.
- W2009703085 countsByYear W20097030852012 @default.
- W2009703085 countsByYear W20097030852015 @default.
- W2009703085 crossrefType "journal-article" @default.
- W2009703085 hasAuthorship W2009703085A5003664573 @default.
- W2009703085 hasAuthorship W2009703085A5020421670 @default.
- W2009703085 hasAuthorship W2009703085A5020736353 @default.
- W2009703085 hasAuthorship W2009703085A5032066228 @default.
- W2009703085 hasAuthorship W2009703085A5044602168 @default.
- W2009703085 hasAuthorship W2009703085A5045384053 @default.
- W2009703085 hasAuthorship W2009703085A5048720703 @default.
- W2009703085 hasAuthorship W2009703085A5049781283 @default.
- W2009703085 hasAuthorship W2009703085A5061179981 @default.
- W2009703085 hasAuthorship W2009703085A5084773667 @default.
- W2009703085 hasBestOaLocation W20097030851 @default.
- W2009703085 hasConcept C126322002 @default.
- W2009703085 hasConcept C141071460 @default.
- W2009703085 hasConcept C2776694085 @default.
- W2009703085 hasConcept C2777063308 @default.
- W2009703085 hasConcept C2778119113 @default.
- W2009703085 hasConcept C2778239845 @default.
- W2009703085 hasConcept C2778850193 @default.
- W2009703085 hasConcept C2780258809 @default.
- W2009703085 hasConcept C2781413609 @default.
- W2009703085 hasConcept C29730261 @default.
- W2009703085 hasConcept C31760486 @default.
- W2009703085 hasConcept C71924100 @default.
- W2009703085 hasConcept C90924648 @default.
- W2009703085 hasConceptScore W2009703085C126322002 @default.
- W2009703085 hasConceptScore W2009703085C141071460 @default.
- W2009703085 hasConceptScore W2009703085C2776694085 @default.
- W2009703085 hasConceptScore W2009703085C2777063308 @default.
- W2009703085 hasConceptScore W2009703085C2778119113 @default.
- W2009703085 hasConceptScore W2009703085C2778239845 @default.
- W2009703085 hasConceptScore W2009703085C2778850193 @default.
- W2009703085 hasConceptScore W2009703085C2780258809 @default.
- W2009703085 hasConceptScore W2009703085C2781413609 @default.
- W2009703085 hasConceptScore W2009703085C29730261 @default.
- W2009703085 hasConceptScore W2009703085C31760486 @default.
- W2009703085 hasConceptScore W2009703085C71924100 @default.
- W2009703085 hasConceptScore W2009703085C90924648 @default.
- W2009703085 hasLocation W20097030851 @default.
- W2009703085 hasLocation W20097030852 @default.
- W2009703085 hasOpenAccess W2009703085 @default.
- W2009703085 hasPrimaryLocation W20097030851 @default.
- W2009703085 hasRelatedWork W2003291927 @default.
- W2009703085 hasRelatedWork W2077567025 @default.
- W2009703085 hasRelatedWork W2349270370 @default.
- W2009703085 hasRelatedWork W2350964097 @default.
- W2009703085 hasRelatedWork W2367470826 @default.
- W2009703085 hasRelatedWork W2375114088 @default.
- W2009703085 hasRelatedWork W2413941024 @default.
- W2009703085 hasRelatedWork W2729666980 @default.
- W2009703085 hasRelatedWork W2746579122 @default.
- W2009703085 hasRelatedWork W3032035276 @default.
- W2009703085 isParatext "false" @default.
- W2009703085 isRetracted "false" @default.
- W2009703085 magId "2009703085" @default.
- W2009703085 workType "article" @default.