FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009705319> ?p ?o ?g. }

• W2009705319 endingPage "4515" @default.
• W2009705319 startingPage "4508" @default.
• W2009705319 abstract "Protein B23 is an abundant nucleolar protein and a putative ribosome assembly factor which possesses an intrinsic ribonuclease activity. In the current work, the effects of RNA sequence and secondary structure on the cleavage preference by protein B23 were studied. Protein B23 ribonuclease preferentially cleaved the single-stranded homopolymers poly(A), poly(U) and poly(C). However, double-stranded co-polymers and poly(G) were resistant to cleavage. No base specificity was observed with an oligoribonucleotide substrate. The action of protein B23 ribonuclease on different regions of pre-rRNA was studied using transcripts synthesized in vitro from cloned rDNA segments. Although no specific cleavages were detected in transcripts containing sequences from the 5′ external transcribed spacer or the first internal transcribed spacer, the enzyme preferentially cleaved the second internal transcribed spacer (ITS2) ∼250 nt downstream from the 3′-end of 5.8S rRNA. Preferential cleavage was retained when the transcript was extended by 100 nt at the 3′-end, but abolished in a transcript lacking this cleavage site. Furthermore, this site was not susceptible to cleavage by RNase A or RNase T1. These results, in conjunction with the sub-nucleolar localization of the protein with elements of the processing machinery, suggest that the protein B23 endoribonuclease could play a role in pre-rRNA processing in ITS2." @default.
• W2009705319 created "2016-06-24" @default.
• W2009705319 creator A5008073185 @default.
• W2009705319 creator A5090943804 @default.
• W2009705319 date "1998-10-01" @default.
• W2009705319 modified "2023-10-17" @default.
• W2009705319 title "Preferential cleavage in pre-ribosomal RNA byprotein B23 endoribonuclease" @default.
• W2009705319 cites W1467606010 @default.
• W2009705319 cites W1583389738 @default.
• W2009705319 doi "https://doi.org/10.1093/nar/26.19.4508" @default.
• W2009705319 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/147876" @default.
• W2009705319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9742256" @default.
• W2009705319 hasPublicationYear "1998" @default.
• W2009705319 type Work @default.
• W2009705319 sameAs 2009705319 @default.
• W2009705319 citedByCount "212" @default.
• W2009705319 countsByYear W20097053192012 @default.
• W2009705319 countsByYear W20097053192013 @default.
• W2009705319 countsByYear W20097053192014 @default.
• W2009705319 countsByYear W20097053192015 @default.
• W2009705319 countsByYear W20097053192016 @default.
• W2009705319 countsByYear W20097053192017 @default.
• W2009705319 countsByYear W20097053192018 @default.
• W2009705319 countsByYear W20097053192019 @default.
• W2009705319 countsByYear W20097053192020 @default.
• W2009705319 countsByYear W20097053192021 @default.
• W2009705319 countsByYear W20097053192022 @default.
• W2009705319 countsByYear W20097053192023 @default.
• W2009705319 crossrefType "journal-article" @default.
• W2009705319 hasAuthorship W2009705319A5008073185 @default.
• W2009705319 hasAuthorship W2009705319A5090943804 @default.
• W2009705319 hasBestOaLocation W20097053191 @default.
• W2009705319 hasConcept C104317684 @default.
• W2009705319 hasConcept C10879258 @default.
• W2009705319 hasConcept C133672593 @default.
• W2009705319 hasConcept C142575336 @default.
• W2009705319 hasConcept C151730666 @default.
• W2009705319 hasConcept C153911025 @default.
• W2009705319 hasConcept C155794727 @default.
• W2009705319 hasConcept C166703698 @default.
• W2009705319 hasConcept C175156509 @default.
• W2009705319 hasConcept C195500695 @default.
• W2009705319 hasConcept C2778976237 @default.
• W2009705319 hasConcept C2780102198 @default.
• W2009705319 hasConcept C38062823 @default.
• W2009705319 hasConcept C43369102 @default.
• W2009705319 hasConcept C55493867 @default.
• W2009705319 hasConcept C62531158 @default.
• W2009705319 hasConcept C67492840 @default.
• W2009705319 hasConcept C67705224 @default.
• W2009705319 hasConcept C67905577 @default.
• W2009705319 hasConcept C69766542 @default.
• W2009705319 hasConcept C79750893 @default.
• W2009705319 hasConcept C86803240 @default.
• W2009705319 hasConcept C88478588 @default.
• W2009705319 hasConceptScore W2009705319C104317684 @default.
• W2009705319 hasConceptScore W2009705319C10879258 @default.
• W2009705319 hasConceptScore W2009705319C133672593 @default.
• W2009705319 hasConceptScore W2009705319C142575336 @default.
• W2009705319 hasConceptScore W2009705319C151730666 @default.
• W2009705319 hasConceptScore W2009705319C153911025 @default.
• W2009705319 hasConceptScore W2009705319C155794727 @default.
• W2009705319 hasConceptScore W2009705319C166703698 @default.
• W2009705319 hasConceptScore W2009705319C175156509 @default.
• W2009705319 hasConceptScore W2009705319C195500695 @default.
• W2009705319 hasConceptScore W2009705319C2778976237 @default.
• W2009705319 hasConceptScore W2009705319C2780102198 @default.
• W2009705319 hasConceptScore W2009705319C38062823 @default.
• W2009705319 hasConceptScore W2009705319C43369102 @default.
• W2009705319 hasConceptScore W2009705319C55493867 @default.
• W2009705319 hasConceptScore W2009705319C62531158 @default.
• W2009705319 hasConceptScore W2009705319C67492840 @default.
• W2009705319 hasConceptScore W2009705319C67705224 @default.
• W2009705319 hasConceptScore W2009705319C67905577 @default.
• W2009705319 hasConceptScore W2009705319C69766542 @default.
• W2009705319 hasConceptScore W2009705319C79750893 @default.
• W2009705319 hasConceptScore W2009705319C86803240 @default.
• W2009705319 hasConceptScore W2009705319C88478588 @default.
• W2009705319 hasIssue "19" @default.
• W2009705319 hasLocation W20097053191 @default.
• W2009705319 hasLocation W20097053192 @default.
• W2009705319 hasLocation W20097053193 @default.
• W2009705319 hasLocation W20097053194 @default.
• W2009705319 hasOpenAccess W2009705319 @default.
• W2009705319 hasPrimaryLocation W20097053191 @default.
• W2009705319 hasRelatedWork W2009705319 @default.
• W2009705319 hasRelatedWork W2049721980 @default.
• W2009705319 hasRelatedWork W2055191397 @default.
• W2009705319 hasRelatedWork W2079923684 @default.
• W2009705319 hasRelatedWork W2113019210 @default.
• W2009705319 hasRelatedWork W2116086283 @default.
• W2009705319 hasRelatedWork W2133459149 @default.
• W2009705319 hasRelatedWork W2146318460 @default.
• W2009705319 hasRelatedWork W2170844769 @default.
• W2009705319 hasRelatedWork W4321502456 @default.
• W2009705319 hasVolume "26" @default.
• W2009705319 isParatext "false" @default.
• W2009705319 isRetracted "false" @default.

• next