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• W2009706913 abstract "An l-glutamine antagonist, 6-diazo-5-oxo-l-norleucin (l-DON), inhibits replication of vesicular stomatitis virus, poliovirus and paramyxoviruses in cultured cells. We tested the antiviral activity of l-DON against different strains of herpes simplex virus type 1 (HSV-1) in Vero cells. In the presence of a physiological plasma concentration of l-glutamine (0.5 mM) l-Don inhibited 50% production of virus plaques at concentrations ranging from 7.9 to 16 μM. At concentrations of 40 μM l-Don inhibited infectious virus yield by 99%. The antiviral activity of l-DON decreased with increasing l-glutamine concentrations. A concentration of 5000 μM of l-Don had no significant effects on the viability of Vero cells. Transmission electron microscopical investigations showed that l-DON prevented mainly envelopment of viral nucleocapsids in the cytoplasm. The immunoprecipitation experiments demonstrated selective inhibition of synthesis of HSV-1 glycoproteins in l-DON treated cells. The results showed that l-DON inhibits HSV-1 replication at a late stage in the virus replication cycle, probably the cytoplasmic maturation of virions and subsequent virion egress from the cells." @default.
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• W2009706913 date "1997-02-01" @default.
• W2009706913 modified "2023-10-10" @default.
• W2009706913 title "Antiviral effects of 6-diazo-5-oxo-l-norleucin on replication of herpes simplex virus type 1" @default.
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• W2009706913 doi "https://doi.org/10.1016/s0166-3542(96)01012-1" @default.
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