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• W2009711053 abstract "ABSTRACT Obesity and obesity related disorders are strongly associated with chronic low-grade inflammation originating from growing visceral adipose tissue during nutrient excess. Although interleukin (IL)-33 may have protective role in obesity and atherosclerosis, the impact of IL-33/ST2 axis in metabolic disorders needs to be elucidated. In this study, we investigated the role of IL-33/ST2 pathway in high-fat diet (HFD)-induced obesity using ST2-deficient (ST2 -/- ) and wild type mice on BALB/c background. The deletion of ST2 enhanced systemic and visceral adipose tissue (VAT) inflammation and was associated with significantly higher weight gain and amount of total VAT in ST2 -/- mice fed with HFD for 18 weeks. More numerous classically activated M1 macrophages and markedly decreased alternatively activated M2 macrophages were observed in VAT of HFD-fed ST2 -/- mice. Additionally, VAT of ST2 -/- mice fed with HFD had increased percentage of CD3 + T cells with lower incidence of CD4 + CD25 + FoxP3 + T regulatory cells in comparison with low-fat diet fed controls. The incidence of CD3 + IL-17 + and IL-5 positive VAT-derived mononuclear cells was significantly lower in HFD-fed ST2 -/- mice. Serum levels of proinflammatory cytokines IL-1β and IFN-γ were increased in HFD-fed ST2 -/- mice, while the levels of IL-6 and CRP did not differ among groups. Importantly, the levels of anti-inflammatory IL-10 and IL-13 were significantly lower in the sera of ST2 -/- mice compared with wild-type controls. Our findings suggest that protective role of IL33/ST2 signaling in high-fat diet-induced adipose tissue inflammation. ST2 deficiency related to nutrient excess is associated with polarization of macrophages toward M1 phenotype and the induction Th1-mediated immune response. Key words: ST2, obesity, high-fat diet, visceral adipose tissue, inflammation" @default.
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• W2009711053 date "2013-01-01" @default.
• W2009711053 modified "2023-09-26" @default.
• W2009711053 title "Lack of ST2 enhances high-fat diet-induced visceral adiposity and inflammation in BALB/c mice" @default.
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• W2009711053 doi "https://doi.org/10.5937/sjecr14-5243" @default.
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