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- W2009713885 abstract "PCDDs and PCDFs were administered as fly ash (500 mg) or fly ash extract to male Wistar rats. The extract was administered orally and intravenously by using arachidis oil and miglyol 812 as oily vehicles. Liver retentions were determined after 48 hours as a degree of bioavailability. In all experiments only the 2,3,7,8-substituted congeners, with the exception of 2,3,4,6,7-PnCDF, were detected in the liver. The dose was 10 to 40 ng for each congener. The lowest bioavailability was found in the experiments with crude or hydrochloric acid pretreated fly ash. Liver retentions were comparable for both experiments with fly ash (0.4 – 3.8%) and were approximately 10 times higher in the oral experiments with oily vehicles. Miglyol 812 produced slightly lower liver retentions compared with arachidis oil. Intravenous dosage with miglyol 812 resulted in liver retentions twice as high as oral administration with this vehicle." @default.
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- W2009713885 date "1987-01-01" @default.
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- W2009713885 title "Vehicle dependent bioavailability of polychlorinated dibenzo-p-dioxins (PCDDs) and -dibenzofurans (PCDFs) in the rat" @default.
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- W2009713885 doi "https://doi.org/10.1016/0045-6535(87)90056-7" @default.
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