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• W2009721399 abstract "Burkitt’s lymphoma (BL) is a high-grade non-Hodgkin lymphoma (NHL) of B-cell origin. It was first described by Dennis Burkitt in Uganda in 1958 as a jaw sarcoma occurring at a high frequency in African children. 1 Burkitt D. A sarcoma involving the jaws in African children. Br J Surg. 1958; 46: 218-221 Google Scholar It accounts for 3% to 5% of all lymphomas and 40% of NHL in children. 2 Diebold J. Jaffe E.S. Raphael M. Warnke R.A. Burkitt’s lymphoma. in: Jaffe E.S. Harris N.L. Stein H. Vardiman J.W. WHO Classification of tumours Pathology and genetics of tumours of haematopoietic and lymphoid tissues. IARC Press, Lyon2001: 181-184 Google Scholar , 3 Shapira J. Peylan-Ramu N. Burkitt’s lymphoma. Oral Oncol. 1998; 34: 15-23 Google Scholar There are 3 clinical variants of BL, each manifesting differences in clinical presentation, morphology, and biology of BL: the endemic (eBL) or African, the sporadic (sBL) or American, and the human immunodeficiency virus–related BL (HIV-BL). The eBL appears primarily but not exclusively in equatorial Africa. The sBL affects mostly white people throughout the world, but especially people in northern America and Europe. 2 Diebold J. Jaffe E.S. Raphael M. Warnke R.A. Burkitt’s lymphoma. in: Jaffe E.S. Harris N.L. Stein H. Vardiman J.W. WHO Classification of tumours Pathology and genetics of tumours of haematopoietic and lymphoid tissues. IARC Press, Lyon2001: 181-184 Google Scholar The annual incidence of BL is low, 1% to 10% of all lymphomas in western countries and 20 to 40 times lower than in Africa and northern Brazil. 3 Shapira J. Peylan-Ramu N. Burkitt’s lymphoma. Oral Oncol. 1998; 34: 15-23 Google Scholar Translocation involving MYC is a constant genetic feature, whereas Epstein-Barr virus (EBV) is found in a variable proportion of cases. 2 Diebold J. Jaffe E.S. Raphael M. Warnke R.A. Burkitt’s lymphoma. in: Jaffe E.S. Harris N.L. Stein H. Vardiman J.W. WHO Classification of tumours Pathology and genetics of tumours of haematopoietic and lymphoid tissues. IARC Press, Lyon2001: 181-184 Google Scholar , 3 Shapira J. Peylan-Ramu N. Burkitt’s lymphoma. Oral Oncol. 1998; 34: 15-23 Google Scholar , 4 Banthia V. Jen A. Kacker A. Sporadic Burkitt’s lymphoma of the head and neck in pediatric population. Int J Pediatric Otorhinolaryngol. 2003; 67: 59-65 Google Scholar , 5 Pear W.S. Ingnarsson S. Steffen D. Munke M. Francke U. Mazin H. et al. Multiple chromosomal rearrangements in a spontaneously arising t(6;7) rat immunocytoma juxrtrapose c-myc and immunoglobulin heavy chain sequences. Proc Natl Acad Sci U S A. 1986; 83: 7376-7380 Google Scholar In this article we present 2 cases of BL affecting the head and neck areas of 2 white boys. One of them exhibited loss of the long arm of chromosome 1, which, to our knowledge, has never been reported in the international literature." @default.
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• W2009721399 title "Burkitt’s lymphoma with loss of the long arm of chromosome 1" @default.
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