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- W2009733990 abstract "Abstract The aromatic polyamidine tetra- p -amidinophenoxyneopentane (TAPP), a compound exhibiting strong anti tumor activity both ‘in vivo’ and ‘in vitro’, was tested for the ability to bind DNA and to interfere with protein-DNA interactions. In this paper we show that TAPP binds DNA and inhibits the binding of the nuclear protein factors GTATA/IFN-γ, OTF-1, NFE-1 and Sp1 with specific target DNA sequences present in the HLA-DRα gene, in the γ-globin gene and in the LTR of HIV-1. These inhibitory effects of TAPP are comparable to those of distamycin, a DNA-binding drug able to suppress DNA-protein interactions. The gel retardation approach described in the present paper could represent a powerful tool to identify potential antitumor and antiviral drugs." @default.
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- W2009733990 date "1991-06-01" @default.
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- W2009733990 title "TAPP (tetra-p-amidinophenoxyneopentane) inhibits the binding of nuclear factors to target DNA sequences" @default.
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- W2009733990 doi "https://doi.org/10.1016/0378-5173(91)90115-5" @default.
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