Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009736484> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2009736484 abstract "The control of cell fate vexes developmental biologists. The vertebrate retina is often used as a model system, because the neural retina contains seven different cell types, all derived from common precursor cells and with birth dates showing distinct temporal patterns. McFarlane et al.1xA role for fibroblast growth factor receptor in cell fate decisions in the developing vertebrate retina. McFarlane, S. Development. 1998; 125: 3967 3975PubMedSee all References1 demonstrate that several FGF receptors (FGFRs) are expressed in retinal precursor cells and that these FGFRs have a profound influence over specific cell fate decisions. By expressing a dominant-negative form of FGFR in the developing retina, a large increase in Muller cell numbers occurs at the expense of rod photoreceptors and amacrine neurons. This appears not to be an effect of selective cell death, or a temporal shift in cell birth dates or differentiation. Instead, it seems that the decision to become a rod or amacrine cell requires the receipt of an FGFR signal. Without the FGFR signal a Muller cell develops, either as a default or alongside additional, Muller-specific signals. In a further twist, retinal overexpression of HAVO, an FGFR that responds to FGF but not to some other non-FGF ligands, results in increased photoreceptors at the expense of amacrine and Muller cells. These novel findings indicate that specific cell fate decisions can be decided by a fine balance between agonistic and antagonistic signals acting through the same FGFR." @default.
- W2009736484 created "2016-06-24" @default.
- W2009736484 creator A5004743588 @default.
- W2009736484 date "1999-01-01" @default.
- W2009736484 modified "2023-09-27" @default.
- W2009736484 title "Deciding cell fate" @default.
- W2009736484 cites W2138266882 @default.
- W2009736484 doi "https://doi.org/10.1016/s0168-9525(98)01675-8" @default.
- W2009736484 hasPublicationYear "1999" @default.
- W2009736484 type Work @default.
- W2009736484 sameAs 2009736484 @default.
- W2009736484 citedByCount "0" @default.
- W2009736484 crossrefType "journal-article" @default.
- W2009736484 hasAuthorship W2009736484A5004743588 @default.
- W2009736484 hasConcept C104317684 @default.
- W2009736484 hasConcept C124964019 @default.
- W2009736484 hasConcept C1491633281 @default.
- W2009736484 hasConcept C163952510 @default.
- W2009736484 hasConcept C169760540 @default.
- W2009736484 hasConcept C170493617 @default.
- W2009736484 hasConcept C189014844 @default.
- W2009736484 hasConcept C201750760 @default.
- W2009736484 hasConcept C2777093970 @default.
- W2009736484 hasConcept C2777102633 @default.
- W2009736484 hasConcept C2778658801 @default.
- W2009736484 hasConcept C2780827179 @default.
- W2009736484 hasConcept C28328180 @default.
- W2009736484 hasConcept C54355233 @default.
- W2009736484 hasConcept C55493867 @default.
- W2009736484 hasConcept C74373430 @default.
- W2009736484 hasConcept C82867764 @default.
- W2009736484 hasConcept C86339819 @default.
- W2009736484 hasConcept C86803240 @default.
- W2009736484 hasConcept C95444343 @default.
- W2009736484 hasConceptScore W2009736484C104317684 @default.
- W2009736484 hasConceptScore W2009736484C124964019 @default.
- W2009736484 hasConceptScore W2009736484C1491633281 @default.
- W2009736484 hasConceptScore W2009736484C163952510 @default.
- W2009736484 hasConceptScore W2009736484C169760540 @default.
- W2009736484 hasConceptScore W2009736484C170493617 @default.
- W2009736484 hasConceptScore W2009736484C189014844 @default.
- W2009736484 hasConceptScore W2009736484C201750760 @default.
- W2009736484 hasConceptScore W2009736484C2777093970 @default.
- W2009736484 hasConceptScore W2009736484C2777102633 @default.
- W2009736484 hasConceptScore W2009736484C2778658801 @default.
- W2009736484 hasConceptScore W2009736484C2780827179 @default.
- W2009736484 hasConceptScore W2009736484C28328180 @default.
- W2009736484 hasConceptScore W2009736484C54355233 @default.
- W2009736484 hasConceptScore W2009736484C55493867 @default.
- W2009736484 hasConceptScore W2009736484C74373430 @default.
- W2009736484 hasConceptScore W2009736484C82867764 @default.
- W2009736484 hasConceptScore W2009736484C86339819 @default.
- W2009736484 hasConceptScore W2009736484C86803240 @default.
- W2009736484 hasConceptScore W2009736484C95444343 @default.
- W2009736484 hasLocation W20097364841 @default.
- W2009736484 hasOpenAccess W2009736484 @default.
- W2009736484 hasPrimaryLocation W20097364841 @default.
- W2009736484 hasRelatedWork W1584614248 @default.
- W2009736484 hasRelatedWork W1604956957 @default.
- W2009736484 hasRelatedWork W1751202325 @default.
- W2009736484 hasRelatedWork W2012819063 @default.
- W2009736484 hasRelatedWork W2026591252 @default.
- W2009736484 hasRelatedWork W2031596923 @default.
- W2009736484 hasRelatedWork W2032751739 @default.
- W2009736484 hasRelatedWork W2044470488 @default.
- W2009736484 hasRelatedWork W2051641091 @default.
- W2009736484 hasRelatedWork W2052108867 @default.
- W2009736484 hasRelatedWork W2069091386 @default.
- W2009736484 hasRelatedWork W2079897953 @default.
- W2009736484 hasRelatedWork W2093347794 @default.
- W2009736484 hasRelatedWork W2125509137 @default.
- W2009736484 hasRelatedWork W2150644687 @default.
- W2009736484 hasRelatedWork W2169250880 @default.
- W2009736484 hasRelatedWork W2488194488 @default.
- W2009736484 hasRelatedWork W2899761016 @default.
- W2009736484 hasRelatedWork W2905295629 @default.
- W2009736484 hasRelatedWork W304767587 @default.
- W2009736484 isParatext "false" @default.
- W2009736484 isRetracted "false" @default.
- W2009736484 magId "2009736484" @default.
- W2009736484 workType "article" @default.