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- W2009747220 abstract "Structural changes reported in the airways of asthmatics include epithelial fragility, goblet cell hyperplasia, enlarged submucosal mucus glands, angiogenesis, increased matrix deposition in the airway wall, increased airway smooth muscle mass, wall thickening and abnormalities in elastin. Genetic influences, as well as fetal and early life exposures, may contribute to structural changes such as subepithelial fibrosis from an early age. Other structural alterations are related to duration of disease and/or long-term uncontrolled inflammation. The increase in smooth muscle mass in both large and small airways probably occurs via multiple mechanisms, and there are probably changes in the phenotype of smooth muscle cells, some showing enhanced synthetic capacity, others enhanced proliferation or contractility. Fixed airflow limitation is probably due to remodelling, whereas the importance of structural changes to the phenomenon of airways hyperresponsiveness may be dependent on the specific clinical phenotype of asthma evaluated. Reduced compliance of the airway wall secondary to enhanced matrix deposition may protect against airway narrowing. Conversely, in severe asthma, disruption of alveolar attachments and adventitial thickening may augment airway narrowing. The encroachment upon luminal area by submucosal thickening may be disadvantageous by increasing the risk of airway closure in the presence of the intraluminal cellular and mucus exudate associated with asthma exacerbations. Structural changes may increase airway narrowing by alteration of smooth muscle dynamics through limitation of the ability of the smooth muscle to periodically lengthen." @default.
- W2009747220 created "2016-06-24" @default.
- W2009747220 creator A5030526109 @default.
- W2009747220 creator A5089807785 @default.
- W2009747220 date "2005-05-24" @default.
- W2009747220 modified "2023-09-27" @default.
- W2009747220 title "Structural changes in the airways in asthma: observations and consequences" @default.
- W2009747220 cites W1657740120 @default.
- W2009747220 cites W1805755361 @default.
- W2009747220 cites W1889388229 @default.
- W2009747220 cites W1894440115 @default.
- W2009747220 cites W1897928961 @default.
- W2009747220 cites W1898356340 @default.
- W2009747220 cites W1898374240 @default.
- W2009747220 cites W1900945426 @default.
- W2009747220 cites W1921627867 @default.
- W2009747220 cites W1939794338 @default.
- W2009747220 cites W1961077570 @default.
- W2009747220 cites W1963513289 @default.
- W2009747220 cites W1964887533 @default.
- W2009747220 cites W1967722955 @default.
- W2009747220 cites W1968723792 @default.
- W2009747220 cites W1969306156 @default.
- W2009747220 cites W1969531702 @default.
- W2009747220 cites W1969692558 @default.
- W2009747220 cites W1970199527 @default.
- W2009747220 cites W1972255710 @default.
- W2009747220 cites W1974371579 @default.
- W2009747220 cites W1975373828 @default.
- W2009747220 cites W1979914322 @default.
- W2009747220 cites W1981720530 @default.
- W2009747220 cites W1985962986 @default.
- W2009747220 cites W1986142113 @default.
- W2009747220 cites W1987230599 @default.
- W2009747220 cites W1989260226 @default.
- W2009747220 cites W1989423035 @default.
- W2009747220 cites W1995266481 @default.
- W2009747220 cites W1999780808 @default.
- W2009747220 cites W1999788260 @default.
- W2009747220 cites W2008070243 @default.
- W2009747220 cites W2011267749 @default.
- W2009747220 cites W2014273697 @default.
- W2009747220 cites W2014324319 @default.
- W2009747220 cites W2014769346 @default.
- W2009747220 cites W2015064899 @default.
- W2009747220 cites W2016025974 @default.
- W2009747220 cites W2018123076 @default.
- W2009747220 cites W2018186263 @default.
- W2009747220 cites W2018399596 @default.
- W2009747220 cites W2018843539 @default.
- W2009747220 cites W2019609817 @default.
- W2009747220 cites W2023546187 @default.
- W2009747220 cites W2029745290 @default.
- W2009747220 cites W2031695399 @default.
- W2009747220 cites W2032080656 @default.
- W2009747220 cites W2033193277 @default.
- W2009747220 cites W2033425349 @default.
- W2009747220 cites W2034258916 @default.
- W2009747220 cites W2036706758 @default.
- W2009747220 cites W2039252747 @default.
- W2009747220 cites W2039427688 @default.
- W2009747220 cites W2039721686 @default.
- W2009747220 cites W2044625455 @default.
- W2009747220 cites W2049216745 @default.
- W2009747220 cites W2050374048 @default.
- W2009747220 cites W2053444611 @default.
- W2009747220 cites W2053724325 @default.
- W2009747220 cites W2057598548 @default.
- W2009747220 cites W2059799021 @default.
- W2009747220 cites W2061046539 @default.
- W2009747220 cites W2065874166 @default.
- W2009747220 cites W2070661470 @default.
- W2009747220 cites W2072974313 @default.
- W2009747220 cites W2074326572 @default.
- W2009747220 cites W2074435841 @default.
- W2009747220 cites W2075169507 @default.
- W2009747220 cites W2075704874 @default.
- W2009747220 cites W2077083859 @default.
- W2009747220 cites W2077279386 @default.
- W2009747220 cites W2077636836 @default.
- W2009747220 cites W2080764956 @default.
- W2009747220 cites W2081724135 @default.
- W2009747220 cites W2084301755 @default.
- W2009747220 cites W2085600133 @default.
- W2009747220 cites W2085977034 @default.
- W2009747220 cites W2086596741 @default.
- W2009747220 cites W2090898517 @default.
- W2009747220 cites W2093263274 @default.
- W2009747220 cites W2094742854 @default.
- W2009747220 cites W2095731503 @default.
- W2009747220 cites W2096887566 @default.
- W2009747220 cites W2097490698 @default.
- W2009747220 cites W2098372138 @default.
- W2009747220 cites W2102667127 @default.
- W2009747220 cites W2102824996 @default.
- W2009747220 cites W2103537973 @default.
- W2009747220 cites W2103853238 @default.
- W2009747220 cites W2104374893 @default.