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• W2009753741 abstract "Abstract. Cytochromes P450 (P450) are a family of isozymes which play an important role in xenobiotic metabolism. The concentration of three P450 isozymes, namely P450-IIEl(Alc),-HIA(NF) and -IIC8-10(MP) has been measured in human liver biopsies of patients with different alcohol and drug intake status. All these three P450s were expressed in all subjects. Ethanol intake increased P450-IIEl(Alc) content with no effect on the content of the two other P450s. Drug intake (barbiturates) increased both P450-IIIA(NF) and -IIC8-10(MP) content without any effect on P450-IIEl(Alc). This paper brought, at protein level, further evidence of the importance of environmental conditions on P450 isozyme pattern, and therefore, on drug metabolizing capacity of human liver." @default.
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• W2009753741 date "1989-12-01" @default.
• W2009753741 modified "2023-09-23" @default.
• W2009753741 title "Modulation of cytochrome P450 isozymes in human liver, by ethanol and drug intake" @default.
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• W2009753741 doi "https://doi.org/10.1111/j.1365-2362.1989.tb00273.x" @default.
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