Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009755744> ?p ?o ?g. }
- W2009755744 abstract "Cytosolic NOD-like receptors (NLRs) have been associated with human diseases including infections, cancer, and autoimmune and inflammatory disorders. These innate immune pattern recognition molecules are essential for controlling inflammatory mechanisms through induction of cytokines, chemokines and antimicrobial genes. Upon activation, some NLRs form multi-protein complexes called inflammasomes, while others orchestrate caspase-independent Nuclear factor kappa B (NF-κB) and Mitogen activated protein kinase (MAPK) signaling. Moreover, NLRs and their downstream signaling components engage in an intricate crosstalk with cell death and autophagy pathways, both critical processes for cancer development. Recently, increasing evidence has extended the concept that chronic inflammation caused by abberant NLR signaling is a powerful driver of carcinogenesis, where it abets genetic mutations, tumor growth and progression. In this review, we explore the rapidly expanding area of research regarding the expression and functions of NLRs in different types of cancers. Furthermore, we particularly focus on how maintaining tissue homeostasis and regulating tissue repair may provide a logical platform for understanding the liaisons between the NLR-driven inflammatory responses and cancer. Finally, we outline novel therapeutic approaches that target NLR signaling and speculate how these could be developed as potential pharmaceutical alternatives for cancer treatment." @default.
- W2009755744 created "2016-06-24" @default.
- W2009755744 creator A5038669508 @default.
- W2009755744 creator A5090472768 @default.
- W2009755744 date "2014-07-14" @default.
- W2009755744 modified "2023-10-15" @default.
- W2009755744 title "NOD-Like Receptors: Master Regulators of Inflammation and Cancer" @default.
- W2009755744 cites W127313292 @default.
- W2009755744 cites W1524848610 @default.
- W2009755744 cites W1529674879 @default.
- W2009755744 cites W1642457845 @default.
- W2009755744 cites W1670573097 @default.
- W2009755744 cites W1671630222 @default.
- W2009755744 cites W1756750202 @default.
- W2009755744 cites W1759917824 @default.
- W2009755744 cites W1861000131 @default.
- W2009755744 cites W1927491384 @default.
- W2009755744 cites W1954263225 @default.
- W2009755744 cites W1965037168 @default.
- W2009755744 cites W1965607649 @default.
- W2009755744 cites W1965668934 @default.
- W2009755744 cites W1966625479 @default.
- W2009755744 cites W1966841369 @default.
- W2009755744 cites W1967535998 @default.
- W2009755744 cites W1968330834 @default.
- W2009755744 cites W1968825280 @default.
- W2009755744 cites W1969603232 @default.
- W2009755744 cites W1969756521 @default.
- W2009755744 cites W1969784891 @default.
- W2009755744 cites W1970154782 @default.
- W2009755744 cites W1971046821 @default.
- W2009755744 cites W1971915082 @default.
- W2009755744 cites W1972093499 @default.
- W2009755744 cites W1972745528 @default.
- W2009755744 cites W1975032025 @default.
- W2009755744 cites W1975296966 @default.
- W2009755744 cites W1975506525 @default.
- W2009755744 cites W1975564825 @default.
- W2009755744 cites W1975870295 @default.
- W2009755744 cites W1976644844 @default.
- W2009755744 cites W1977100459 @default.
- W2009755744 cites W1977258127 @default.
- W2009755744 cites W1979736739 @default.
- W2009755744 cites W1979849717 @default.
- W2009755744 cites W1979991507 @default.
- W2009755744 cites W1981837371 @default.
- W2009755744 cites W1982029015 @default.
- W2009755744 cites W1982718063 @default.
- W2009755744 cites W1983502509 @default.
- W2009755744 cites W1985538633 @default.
- W2009755744 cites W1985970823 @default.
- W2009755744 cites W1986997900 @default.
- W2009755744 cites W1987329700 @default.
- W2009755744 cites W1987433340 @default.
- W2009755744 cites W1990606472 @default.
- W2009755744 cites W1990735654 @default.
- W2009755744 cites W1990955264 @default.
- W2009755744 cites W1991117870 @default.
- W2009755744 cites W1992219661 @default.
- W2009755744 cites W1993079965 @default.
- W2009755744 cites W1993262772 @default.
- W2009755744 cites W1993442154 @default.
- W2009755744 cites W1993728991 @default.
- W2009755744 cites W1994473516 @default.
- W2009755744 cites W1994942139 @default.
- W2009755744 cites W1994987533 @default.
- W2009755744 cites W1996148181 @default.
- W2009755744 cites W1997054509 @default.
- W2009755744 cites W1997572777 @default.
- W2009755744 cites W2000999642 @default.
- W2009755744 cites W2002765518 @default.
- W2009755744 cites W2003634035 @default.
- W2009755744 cites W2005572311 @default.
- W2009755744 cites W2006033910 @default.
- W2009755744 cites W2007747853 @default.
- W2009755744 cites W2008025218 @default.
- W2009755744 cites W2008202400 @default.
- W2009755744 cites W2009004909 @default.
- W2009755744 cites W2009093325 @default.
- W2009755744 cites W2009800174 @default.
- W2009755744 cites W2011197968 @default.
- W2009755744 cites W2011810346 @default.
- W2009755744 cites W2012270515 @default.
- W2009755744 cites W2012272570 @default.
- W2009755744 cites W2013252113 @default.
- W2009755744 cites W2013475718 @default.
- W2009755744 cites W2014544900 @default.
- W2009755744 cites W2015011627 @default.
- W2009755744 cites W2015934540 @default.
- W2009755744 cites W2018439544 @default.
- W2009755744 cites W2018563185 @default.
- W2009755744 cites W2018983895 @default.
- W2009755744 cites W2021731024 @default.
- W2009755744 cites W2024209312 @default.
- W2009755744 cites W2025763309 @default.
- W2009755744 cites W2027748180 @default.
- W2009755744 cites W2028017703 @default.
- W2009755744 cites W2028145763 @default.
- W2009755744 cites W2031113436 @default.
- W2009755744 cites W2031949901 @default.