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- W2009759743 abstract "Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine, regulating inflammatory and immune responses. MIF binds to cell surface receptor CD74, resulting in both rapid and sustained ERK activation. It was reported that MIF-induced rapid ERK activation requires its co-receptor CD44. But the exact mechanism underlying sustained ERK activation is not well understood. In the current study, we described a detailed mechanism of MIF mediated sustained ERK activation. We found that β-arrestin1, a scaffold protein involved in the activation of the MAPK cascade, interacts with CD74 upon MIF stimulation, resulting in CD74-mediated MIF endocytosis in a chlorpromazine (CPZ)-sensitive manner. β-arrestin1 is also involved in endocytotic MIF signaling, leading to sustained ERK activation. Therefore β-arrestin1 plays a central role in coupling MIF endocytosis to sustained ERK activation." @default.
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- W2009759743 date "2011-01-25" @default.
- W2009759743 modified "2023-09-25" @default.
- W2009759743 title "β-Arrestin1 Mediates the Endocytosis and Functions of Macrophage Migration Inhibitory Factor" @default.
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- W2009759743 doi "https://doi.org/10.1371/journal.pone.0016428" @default.
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