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• W2009762425 abstract "The minimum lethal dose of hemicholinium-3 (HC-3) (intra-peritoneal) was determined in groups of male albino mice. Death occurred in the majority of cases within 10 min after injection and was attributed to the “curare-like” action of HC-3. However, pretreatment with ethanol (i.p.) was found to afford protection against these toxic effects. The site of action of ethanol protection appeared to be peripheral since ethanol (i.p.) also protected against a lethal dose of the post-synaptic neuromuscular blocking agent, d-tubocurarine (dtc) (intravenous). The time course of the protection suggested that a metabolite of ethanol might be involved. The phrenic nerve-diaphragm preparation was used to demonstrate the “curare-like” action of HC-3 and to investigate the effect of ethanol on this. Ethanol added to the bathing medium produced a transient reversal of the fall in twitch height produced by either HC-3 or dtc. This reversal may be primarily explained by depolarisation of the post-synaptic membrane by ethanol since this potentiated the blockade due to decamethonium and caused an increase in resting tension of the muscle." @default.
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• W2009762425 date "1975-02-01" @default.
• W2009762425 modified "2023-10-18" @default.
• W2009762425 title "Ethanol protection against hemicholinium toxicity in mice" @default.
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• W2009762425 doi "https://doi.org/10.1016/0006-2952(75)90134-3" @default.
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