FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009771215> ?p ?o ?g. }

• W2009771215 endingPage "1741" @default.
• W2009771215 startingPage "1723" @default.
• W2009771215 abstract "The filamentous fungus Aspergillus clavatus is known to produce a variety of secondary metabolites (SM) such as patulin, pseurotin A, and cytochalasin E. In fungi, the production of most SM is strongly influenced by environmental factors and nutrients. Furthermore, it has been shown that the regulation of SM gene clusters is largely based on modulation of a chromatin structure. Communication between fungi and bacteria also triggers chromatin-based induction of silent SM gene clusters. Consequently, chemical chromatin effectors known to inhibit histone deacetylases (HDACs) and DNA-methyltransferases (DNMTs) influence the SM profile of several fungi. In this study, we tested the effect of five different chemicals, which are known to affect chromatin structure, on SM production in A. clavatus using two growth media with a different organic nitrogen source. We found that production of patulin was completely inhibited and cytochalasin E levels strongly reduced, whereas growing A. clavatus in media containing soya-derived peptone led to substantially higher pseurotin A levels. The HDAC inhibitors valproic acid, trichostatin A and butyrate, as well as the DNMT inhibitor 5-azacytidine (AZA) and N-acetyl-D-glucosamine, which was used as a proxy for bacterial fungal co-cultivation, had profound influence on SM accumulation and transcription of the corresponding biosynthetic genes. However, the repressing effect of the soya-based nitrogen source on patulin production could not be bypassed by any of the small chemical chromatin effectors. Interestingly, AZA influenced some SM cluster genes and SM production although no Aspergillus species has yet been shown to carry detectable DNA methylation." @default.
• W2009771215 created "2016-06-24" @default.
• W2009771215 creator A5020842159 @default.
• W2009771215 creator A5023933418 @default.
• W2009771215 creator A5055488944 @default.
• W2009771215 creator A5067866835 @default.
• W2009771215 creator A5069410693 @default.
• W2009771215 creator A5075067727 @default.
• W2009771215 date "2013-10-07" @default.
• W2009771215 modified "2023-10-01" @default.
• W2009771215 title "Small Chemical Chromatin Effectors Alter Secondary Metabolite Production in Aspergillus clavatus" @default.
• W2009771215 cites W112337693 @default.
• W2009771215 cites W1511815964 @default.
• W2009771215 cites W1559150972 @default.
• W2009771215 cites W1579427908 @default.
• W2009771215 cites W1591955005 @default.
• W2009771215 cites W1965679720 @default.
• W2009771215 cites W1971547399 @default.
• W2009771215 cites W1979367107 @default.
• W2009771215 cites W1987271093 @default.
• W2009771215 cites W1987431889 @default.
• W2009771215 cites W1987464738 @default.
• W2009771215 cites W1988815096 @default.
• W2009771215 cites W1989318771 @default.
• W2009771215 cites W1991276321 @default.
• W2009771215 cites W1991780507 @default.
• W2009771215 cites W1993839684 @default.
• W2009771215 cites W2000373459 @default.
• W2009771215 cites W2001463005 @default.
• W2009771215 cites W2006641300 @default.
• W2009771215 cites W2013647096 @default.
• W2009771215 cites W2014037753 @default.
• W2009771215 cites W2014256804 @default.
• W2009771215 cites W2018309119 @default.
• W2009771215 cites W2029783392 @default.
• W2009771215 cites W2029979826 @default.
• W2009771215 cites W2035462330 @default.
• W2009771215 cites W2038077039 @default.
• W2009771215 cites W2038120079 @default.
• W2009771215 cites W2039250780 @default.
• W2009771215 cites W2041324196 @default.
• W2009771215 cites W2043177548 @default.
• W2009771215 cites W2045444560 @default.
• W2009771215 cites W2046269911 @default.
• W2009771215 cites W2046427889 @default.
• W2009771215 cites W2053421240 @default.
• W2009771215 cites W2055616591 @default.
• W2009771215 cites W2059114461 @default.
• W2009771215 cites W2061338233 @default.
• W2009771215 cites W2063607020 @default.
• W2009771215 cites W2063666894 @default.
• W2009771215 cites W2072536047 @default.
• W2009771215 cites W2073198479 @default.
• W2009771215 cites W2076343183 @default.
• W2009771215 cites W2084425497 @default.
• W2009771215 cites W2090423609 @default.
• W2009771215 cites W2091185055 @default.
• W2009771215 cites W2097343652 @default.
• W2009771215 cites W2099716066 @default.
• W2009771215 cites W2101205619 @default.
• W2009771215 cites W2104020718 @default.
• W2009771215 cites W2104585197 @default.
• W2009771215 cites W2105938928 @default.
• W2009771215 cites W2106775330 @default.
• W2009771215 cites W2106932184 @default.
• W2009771215 cites W2107270084 @default.
• W2009771215 cites W2109491562 @default.
• W2009771215 cites W2109924970 @default.
• W2009771215 cites W2116673819 @default.
• W2009771215 cites W2117691193 @default.
• W2009771215 cites W2118449874 @default.
• W2009771215 cites W2126992172 @default.
• W2009771215 cites W2129994851 @default.
• W2009771215 cites W2130005065 @default.
• W2009771215 cites W2134416111 @default.
• W2009771215 cites W2135454805 @default.
• W2009771215 cites W2136004844 @default.
• W2009771215 cites W2136124050 @default.
• W2009771215 cites W2139892368 @default.
• W2009771215 cites W2140937256 @default.
• W2009771215 cites W2142261306 @default.
• W2009771215 cites W2145109415 @default.
• W2009771215 cites W2153861569 @default.
• W2009771215 cites W2167722126 @default.
• W2009771215 cites W2168785486 @default.
• W2009771215 cites W2170382616 @default.
• W2009771215 cites W2171142920 @default.
• W2009771215 cites W2172067933 @default.
• W2009771215 cites W2895600031 @default.
• W2009771215 cites W4252679422 @default.
• W2009771215 cites W69776591 @default.
• W2009771215 doi "https://doi.org/10.3390/toxins5101723" @default.
• W2009771215 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3813908" @default.
• W2009771215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24105402" @default.
• W2009771215 hasPublicationYear "2013" @default.
• W2009771215 type Work @default.
• W2009771215 sameAs 2009771215 @default.
• W2009771215 citedByCount "38" @default.

• next