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- W2009776483 abstract "The mode of action of antidepressants is still a matter of debate. Acute inhibition of neurotransmitter reuptake in central neuronal synapses, followed by a down-regulation of central postsynaptic β-adrenoceptor (β-AR) numbers were consistently observed in vivo, while a reduction in surface β-AR density was found in cell cultures. Effects of the tricyclic antidepressant desipramine (DMI) were abolished by vitamin E (α-TOC) in vitro as well as in vivo. α-TOC interfered with antidepressant-induced changes of cellular plasma membrane properties and with recycling of β-AR. St. John’s wort (SJW) extract reduced β-AR numbers in cultured cells to a similar extent as DMI or the selective serotonin re-uptake inhibitor fluoxetine. We chronically co-exposed cell cultures to SJW extract and to α-TOC. Receptor down-regulation following exposure to the plant extract was inhibited in the presence of α-TOC suggesting a mode of action of SJW extract comparable to that of synthetic antidepressants. Inhibition of cell proliferation by the plant extract was also significantly reduced by α-TOC." @default.
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- W2009776483 date "2006-12-01" @default.
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- W2009776483 title "Vitamin E Reduces Antidepressant-Related β-Adrenoceptor Down-Regulation in Cultured Cells. Comparable Effects on St. John’s Wort and Tricyclic Antidepressant Treatment" @default.
- W2009776483 doi "https://doi.org/10.1055/s-2006-951727" @default.
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