Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009777112> ?p ?o ?g. }
- W2009777112 endingPage "93" @default.
- W2009777112 startingPage "86" @default.
- W2009777112 abstract "Discovery of tumor vascular specific molecules to improve the targeting ability of cytotoxic agents plays an important role in antiangiogenesis. We had found a peptide GX1 (CGNSNPKSC) binding to vasculature endothelial cells of human gastric cancer by phage display technology and its specificity to vasculature had been thoroughly confirmed in vitro. To further evaluate the applicability of GX1 in antiangiogenesis therapy of gastric cancer, immunohistochemical analysis and ECT imaging in nude mice were performed. Immunohistochemical analysis showed that GX1 phage produced positive staining on 51/65 (78%) cases of the vasculature of gastric cancer. Simultaneously GX1 peptide was labeled with (99)Tc(m)O(4)(-), which obtained with high labeling efficiency. (99)Tc(m)-GX1 could specifically bind to Co-HUVEC and HUVEC with a binding constant of 3062 pM and 3831 pM respectively. ECT imaging indicated that GX1 could efficiently target to xenographic tissue in mice model with a high tumor/heart radio than that of control peptide. Biodistribution showed that tumor uptake was 0.74+/-0.02% ID/g at 24 h, 11 times than that of muscle. Immunofluorescence showed GX1 peptide could bind to xenograft vasculature in vivo. The results confirmed the targeting specificity of GX1 in gastric cancer-associated angiogenesis. It would be promising to further develop GX1 peptide-based assay for tumor angiogenesis imaging to improve diagnosis and internal radiotherapy." @default.
- W2009777112 created "2016-06-24" @default.
- W2009777112 creator A5005706767 @default.
- W2009777112 creator A5014770097 @default.
- W2009777112 creator A5016501019 @default.
- W2009777112 creator A5018083882 @default.
- W2009777112 creator A5025590520 @default.
- W2009777112 creator A5027501932 @default.
- W2009777112 creator A5027992006 @default.
- W2009777112 creator A5030661910 @default.
- W2009777112 creator A5037677450 @default.
- W2009777112 creator A5039566796 @default.
- W2009777112 creator A5051670402 @default.
- W2009777112 creator A5056755738 @default.
- W2009777112 creator A5074800265 @default.
- W2009777112 creator A5082579536 @default.
- W2009777112 creator A5090454610 @default.
- W2009777112 creator A5091448543 @default.
- W2009777112 date "2008-10-01" @default.
- W2009777112 modified "2023-10-14" @default.
- W2009777112 title "Specific targeting of the vasculature of gastric cancer by a new tumor-homing peptide CGNSNPKSC" @default.
- W2009777112 cites W1559937222 @default.
- W2009777112 cites W1573363574 @default.
- W2009777112 cites W1576210721 @default.
- W2009777112 cites W1967587727 @default.
- W2009777112 cites W1983622721 @default.
- W2009777112 cites W1986354324 @default.
- W2009777112 cites W1998162097 @default.
- W2009777112 cites W2000000541 @default.
- W2009777112 cites W2000799481 @default.
- W2009777112 cites W2001753204 @default.
- W2009777112 cites W2002100652 @default.
- W2009777112 cites W2003848116 @default.
- W2009777112 cites W2004602287 @default.
- W2009777112 cites W2008000140 @default.
- W2009777112 cites W2009510043 @default.
- W2009777112 cites W2010947866 @default.
- W2009777112 cites W2012635635 @default.
- W2009777112 cites W2015547104 @default.
- W2009777112 cites W2015615249 @default.
- W2009777112 cites W2022170158 @default.
- W2009777112 cites W2024106944 @default.
- W2009777112 cites W2034350111 @default.
- W2009777112 cites W2044808829 @default.
- W2009777112 cites W2045702474 @default.
- W2009777112 cites W2046507292 @default.
- W2009777112 cites W2047150580 @default.
- W2009777112 cites W2058048379 @default.
- W2009777112 cites W2064656479 @default.
- W2009777112 cites W2065246138 @default.
- W2009777112 cites W2066308207 @default.
- W2009777112 cites W2066503773 @default.
- W2009777112 cites W2077391174 @default.
- W2009777112 cites W2084740377 @default.
- W2009777112 cites W2088564414 @default.
- W2009777112 cites W2093867530 @default.
- W2009777112 cites W2094364086 @default.
- W2009777112 cites W2100363932 @default.
- W2009777112 cites W2113813607 @default.
- W2009777112 cites W2116121153 @default.
- W2009777112 cites W2123963487 @default.
- W2009777112 cites W2124711449 @default.
- W2009777112 cites W2134077476 @default.
- W2009777112 cites W2145263059 @default.
- W2009777112 cites W2153381032 @default.
- W2009777112 cites W2155807129 @default.
- W2009777112 cites W2157769714 @default.
- W2009777112 cites W2164027212 @default.
- W2009777112 cites W2168409923 @default.
- W2009777112 cites W4250428608 @default.
- W2009777112 doi "https://doi.org/10.1016/j.jconrel.2008.07.024" @default.
- W2009777112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18700158" @default.
- W2009777112 hasPublicationYear "2008" @default.
- W2009777112 type Work @default.
- W2009777112 sameAs 2009777112 @default.
- W2009777112 citedByCount "62" @default.
- W2009777112 countsByYear W20097771122012 @default.
- W2009777112 countsByYear W20097771122013 @default.
- W2009777112 countsByYear W20097771122014 @default.
- W2009777112 countsByYear W20097771122015 @default.
- W2009777112 countsByYear W20097771122016 @default.
- W2009777112 countsByYear W20097771122017 @default.
- W2009777112 countsByYear W20097771122018 @default.
- W2009777112 countsByYear W20097771122019 @default.
- W2009777112 countsByYear W20097771122020 @default.
- W2009777112 countsByYear W20097771122021 @default.
- W2009777112 countsByYear W20097771122023 @default.
- W2009777112 crossrefType "journal-article" @default.
- W2009777112 hasAuthorship W2009777112A5005706767 @default.
- W2009777112 hasAuthorship W2009777112A5014770097 @default.
- W2009777112 hasAuthorship W2009777112A5016501019 @default.
- W2009777112 hasAuthorship W2009777112A5018083882 @default.
- W2009777112 hasAuthorship W2009777112A5025590520 @default.
- W2009777112 hasAuthorship W2009777112A5027501932 @default.
- W2009777112 hasAuthorship W2009777112A5027992006 @default.
- W2009777112 hasAuthorship W2009777112A5030661910 @default.
- W2009777112 hasAuthorship W2009777112A5037677450 @default.
- W2009777112 hasAuthorship W2009777112A5039566796 @default.