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• W2009785870 abstract "Using a polymerization inhibition assay, we have purified a small, heat stable protein that physically interacts with tubulin dimers and increases the catastrophe rate of microtubules. Sequence analysis identified this protein as oncoprotein 18 (Op18)/stathmin, a conserved phosphoprotein that is highly expressed in leukemia cells. Immunodepletion experiments in Xenopus egg extracts showed that Op18/stathmin is involved in physiological regulation of mitotic microtubule dynamics. Op18/stathmin is a microtubule regulator that preferentially interacts with unpolymerized subunits. It is a candidate for increasing the microtubule catastrophe rate in mitosis and might also regulate microtubule dynamics in response to external signals." @default.
• W2009785870 created "2016-06-24" @default.
• W2009785870 creator A5059124650 @default.
• W2009785870 creator A5074302940 @default.
• W2009785870 date "1996-02-01" @default.
• W2009785870 modified "2023-10-12" @default.
• W2009785870 title "Identification of a Protein That Interacts with Tubulin Dimers and Increases the Catastrophe Rate of Microtubules" @default.
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• W2009785870 doi "https://doi.org/10.1016/s0092-8674(00)81037-5" @default.
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