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• W2009799652 abstract "Because sulfur and selenium antioxidants can prevent oxidative damage, numerous animal and clinical trials have investigated the ability of these compounds to prevent the oxidative stress that is an underlying cause of cardiovascular disease, Alzheimer's disease, and cancer, among others. One of the most common sources of oxidative damage is metal-generated hydroxyl radical; however, very little research has focused on determining the metal-binding abilities and structural attributes that affect oxidative damage prevention by sulfur and selenium compounds. In this review, we describe our ongoing investigations into sulfur and selenium antioxidant prevention of iron- and copper-mediated oxidative DNA damage. We determined that many sulfur and selenium compounds inhibit CuI-mediated DNA damage and that DNA damage prevention varies dramatically when FeII is used in place of CuI to generate hydroxyl radical. Oxidation potentials of the sulfur or selenium compounds do not correlate with their ability to prevent DNA damage, highlighting the importance of metal coordination rather than reactive oxygen species scavenging as an antioxidant mechanism. Additional gel electrophoresis, mass spectrometry, and UV–visible studies confirmed sulfur and selenium antioxidant binding to CuI and FeII. Ultimately, our studies established that both the hydroxyl-radical-generating metal ion and the chemical environment of the sulfur or selenium significantly affect DNA damage prevention and that metal coordination is an essential mechanism for these antioxidants." @default.
• W2009799652 created "2016-06-24" @default.
• W2009799652 creator A5011767249 @default.
• W2009799652 creator A5043833849 @default.
• W2009799652 creator A5071980494 @default.
• W2009799652 creator A5074634487 @default.
• W2009799652 date "2015-04-01" @default.
• W2009799652 modified "2023-10-03" @default.
• W2009799652 title "Sulfur and selenium antioxidants: Challenging radical scavenging mechanisms and developing structure–activity relationships based on metal binding" @default.
• W2009799652 cites W1172203783 @default.
• W2009799652 cites W12892762 @default.
• W2009799652 cites W1512368457 @default.
• W2009799652 cites W1525110894 @default.
• W2009799652 cites W156137099 @default.
• W2009799652 cites W1565617812 @default.
• W2009799652 cites W1575039155 @default.
• W2009799652 cites W1580330659 @default.
• W2009799652 cites W1602425415 @default.
• W2009799652 cites W1924675054 @default.
• W2009799652 cites W1935064934 @default.
• W2009799652 cites W1959593972 @default.
• W2009799652 cites W1964905651 @default.
• W2009799652 cites W1965518837 @default.
• W2009799652 cites W1966386635 @default.
• W2009799652 cites W1966603473 @default.
• W2009799652 cites W1968404967 @default.
• W2009799652 cites W1969490048 @default.
• W2009799652 cites W1970426664 @default.
• W2009799652 cites W1972610941 @default.
• W2009799652 cites W1972995491 @default.
• W2009799652 cites W1973134985 @default.
• W2009799652 cites W1973294011 @default.
• W2009799652 cites W1976177921 @default.
• W2009799652 cites W1976220731 @default.
• W2009799652 cites W1978059664 @default.
• W2009799652 cites W1979372328 @default.
• W2009799652 cites W1980970371 @default.
• W2009799652 cites W1982048806 @default.
• W2009799652 cites W1982870743 @default.
• W2009799652 cites W1983157222 @default.
• W2009799652 cites W1987345465 @default.
• W2009799652 cites W1988077163 @default.
• W2009799652 cites W1990664964 @default.
• W2009799652 cites W1991039509 @default.
• W2009799652 cites W1993323144 @default.
• W2009799652 cites W1994368627 @default.
• W2009799652 cites W1994600867 @default.
• W2009799652 cites W1998227640 @default.
• W2009799652 cites W1998408986 @default.
• W2009799652 cites W1998568899 @default.
• W2009799652 cites W2000829985 @default.
• W2009799652 cites W2000998542 @default.
• W2009799652 cites W2001055223 @default.
• W2009799652 cites W2002698623 @default.
• W2009799652 cites W2004297512 @default.
• W2009799652 cites W2005146296 @default.
• W2009799652 cites W2007062623 @default.
• W2009799652 cites W2007724385 @default.
• W2009799652 cites W2008141541 @default.
• W2009799652 cites W2009464651 @default.
• W2009799652 cites W2010201651 @default.
• W2009799652 cites W2010423257 @default.
• W2009799652 cites W2010930508 @default.
• W2009799652 cites W2011817526 @default.
• W2009799652 cites W2013781623 @default.
• W2009799652 cites W2014455203 @default.
• W2009799652 cites W2014930981 @default.
• W2009799652 cites W2015466535 @default.
• W2009799652 cites W2015598629 @default.
• W2009799652 cites W2015803999 @default.
• W2009799652 cites W2016066239 @default.
• W2009799652 cites W2017935819 @default.
• W2009799652 cites W2021440413 @default.
• W2009799652 cites W2021571789 @default.
• W2009799652 cites W2022229687 @default.
• W2009799652 cites W2022682403 @default.
• W2009799652 cites W2022735447 @default.
• W2009799652 cites W2022976870 @default.
• W2009799652 cites W2023495273 @default.
• W2009799652 cites W2024674434 @default.
• W2009799652 cites W2025914723 @default.
• W2009799652 cites W2026077676 @default.
• W2009799652 cites W2026571268 @default.
• W2009799652 cites W2027598856 @default.
• W2009799652 cites W2027888373 @default.
• W2009799652 cites W2028575675 @default.
• W2009799652 cites W2030045479 @default.
• W2009799652 cites W2030983914 @default.
• W2009799652 cites W2032374132 @default.
• W2009799652 cites W2033023034 @default.
• W2009799652 cites W2035516824 @default.
• W2009799652 cites W2036736548 @default.
• W2009799652 cites W2039198912 @default.
• W2009799652 cites W2039684034 @default.
• W2009799652 cites W2040804698 @default.
• W2009799652 cites W2041430974 @default.
• W2009799652 cites W2041655473 @default.
• W2009799652 cites W2043817490 @default.

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