FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009808992> ?p ?o ?g. }

• W2009808992 endingPage "32" @default.
• W2009808992 startingPage "24" @default.
• W2009808992 abstract "Basal lamina is a major part of the microvascular wall and plays a critical role in the integrity of microvasculature. The aim of this study is to determine whether hyperthermia worsens the destruction of microvascular integrity in the ischaemic injured brain.Focal cerebral ischaemia was induced by embolising a pre-formed clot into the middle cerebral artery (MCA). Rats received either normothermic or hyperthermic treatment. Neurological score and infarct size were evaluated at 24 h after the MCA occlusion. Microvascular collagen type IV and laminin were measured with fluorescence microscopy. The activities of matrix metalloproteinases (MMP-2 and MMP-9) and plasminogen activators (tPA and uPA) were determined by zymography.Treatment with hyperthermia significantly increased infarct volume (p<0.01), cortex swelling (p<0.01), striatum swelling (p<0.05) and neurologic score (p<0.01) at 24 h after the MCA occlusion. Compared to the normothermic groups, hyperthermia significantly worsened the losses of microvascular basal lamina structure proteins, collagen type IV and laminin, at 6 h (p<0.001) and 24 h (p<0.01) after MCA occlusion. Hyperthermia increased the MMP-9 activity at 6 and 24 h after MCA occlusion compared with normothermia (p<0.05), whereas increased the MMP-2 activity at 6 h only (p<0.05). Hyperthermia also elevated uPA activity significantly at 6 and 24 h after MCA occlusion compared to normothermia (p<0.05).These results demonstrate that hyperthermia exacerbates the destruction of microvascular integrity possibly by increasing the activities of MMP-2, MMP-9 and uPA in the ischaemic cerebral tissues." @default.
• W2009808992 created "2016-06-24" @default.
• W2009808992 creator A5023120961 @default.
• W2009808992 creator A5025618294 @default.
• W2009808992 creator A5050507154 @default.
• W2009808992 creator A5077791798 @default.
• W2009808992 date "2012-01-11" @default.
• W2009808992 modified "2023-09-23" @default.
• W2009808992 title "Hyperthermia worsens ischaemic brain injury through destruction of microvessels in an embolic model in rats" @default.
• W2009808992 cites W1495724646 @default.
• W2009808992 cites W1754114568 @default.
• W2009808992 cites W1764824114 @default.
• W2009808992 cites W1970881264 @default.
• W2009808992 cites W1986595185 @default.
• W2009808992 cites W1989171577 @default.
• W2009808992 cites W1990711278 @default.
• W2009808992 cites W1992981081 @default.
• W2009808992 cites W1993720383 @default.
• W2009808992 cites W2011125535 @default.
• W2009808992 cites W2017608595 @default.
• W2009808992 cites W2020500819 @default.
• W2009808992 cites W2026989777 @default.
• W2009808992 cites W2031163563 @default.
• W2009808992 cites W2032362734 @default.
• W2009808992 cites W2035569448 @default.
• W2009808992 cites W2036489895 @default.
• W2009808992 cites W2046247898 @default.
• W2009808992 cites W2049846962 @default.
• W2009808992 cites W2049887416 @default.
• W2009808992 cites W2050054991 @default.
• W2009808992 cites W2053525375 @default.
• W2009808992 cites W2054038482 @default.
• W2009808992 cites W2058902596 @default.
• W2009808992 cites W2059551548 @default.
• W2009808992 cites W2068628534 @default.
• W2009808992 cites W2070543132 @default.
• W2009808992 cites W2074786710 @default.
• W2009808992 cites W2075606347 @default.
• W2009808992 cites W2089679794 @default.
• W2009808992 cites W2113892795 @default.
• W2009808992 cites W2125683177 @default.
• W2009808992 cites W2126394436 @default.
• W2009808992 cites W2126634468 @default.
• W2009808992 cites W2138684097 @default.
• W2009808992 cites W2149116325 @default.
• W2009808992 cites W2155215582 @default.
• W2009808992 cites W2170809171 @default.
• W2009808992 doi "https://doi.org/10.3109/02656736.2011.631963" @default.
• W2009808992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22235782" @default.
• W2009808992 hasPublicationYear "2012" @default.
• W2009808992 type Work @default.
• W2009808992 sameAs 2009808992 @default.
• W2009808992 citedByCount "11" @default.
• W2009808992 countsByYear W20098089922014 @default.
• W2009808992 countsByYear W20098089922015 @default.
• W2009808992 countsByYear W20098089922016 @default.
• W2009808992 countsByYear W20098089922017 @default.
• W2009808992 countsByYear W20098089922018 @default.
• W2009808992 countsByYear W20098089922019 @default.
• W2009808992 countsByYear W20098089922020 @default.
• W2009808992 countsByYear W20098089922021 @default.
• W2009808992 countsByYear W20098089922023 @default.
• W2009808992 crossrefType "journal-article" @default.
• W2009808992 hasAuthorship W2009808992A5023120961 @default.
• W2009808992 hasAuthorship W2009808992A5025618294 @default.
• W2009808992 hasAuthorship W2009808992A5050507154 @default.
• W2009808992 hasAuthorship W2009808992A5077791798 @default.
• W2009808992 hasBestOaLocation W20098089921 @default.
• W2009808992 hasConcept C109523444 @default.
• W2009808992 hasConcept C126322002 @default.
• W2009808992 hasConcept C142724271 @default.
• W2009808992 hasConcept C177430391 @default.
• W2009808992 hasConcept C2775841333 @default.
• W2009808992 hasConcept C2776268601 @default.
• W2009808992 hasConcept C2779333224 @default.
• W2009808992 hasConcept C2779949491 @default.
• W2009808992 hasConcept C42219234 @default.
• W2009808992 hasConcept C541997718 @default.
• W2009808992 hasConcept C71924100 @default.
• W2009808992 hasConcept C87555872 @default.
• W2009808992 hasConceptScore W2009808992C109523444 @default.
• W2009808992 hasConceptScore W2009808992C126322002 @default.
• W2009808992 hasConceptScore W2009808992C142724271 @default.
• W2009808992 hasConceptScore W2009808992C177430391 @default.
• W2009808992 hasConceptScore W2009808992C2775841333 @default.
• W2009808992 hasConceptScore W2009808992C2776268601 @default.
• W2009808992 hasConceptScore W2009808992C2779333224 @default.
• W2009808992 hasConceptScore W2009808992C2779949491 @default.
• W2009808992 hasConceptScore W2009808992C42219234 @default.
• W2009808992 hasConceptScore W2009808992C541997718 @default.
• W2009808992 hasConceptScore W2009808992C71924100 @default.
• W2009808992 hasConceptScore W2009808992C87555872 @default.
• W2009808992 hasIssue "1" @default.
• W2009808992 hasLocation W20098089921 @default.
• W2009808992 hasLocation W20098089922 @default.
• W2009808992 hasOpenAccess W2009808992 @default.
• W2009808992 hasPrimaryLocation W20098089921 @default.
• W2009808992 hasRelatedWork W1972549605 @default.

• next