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- W2009814713 abstract "The effects of Ni(II), administered ip as NiCl2 or NiSO4, upon plasma glucose and serum insulin concentrations have been investigated in Fischer rats. In fasting rats, hyperglycemia occurred at 0.5 hr after injection of Ni(II) in dosages from 12 to 85 μmol/kg. At dosages ≥34 μmol/kg, hyperglycemia persisted for 4 hr after injection of Ni(II). In approximate order of decreasing magnitude and duration, the hyperglycemic responses to equimolar ip injections of divalent ions of selected first transition metals were: Ni ≥ Co ≥ Cu ≥ Zn > Cr > Fe > Mn. Concurrent administration of insulin antagonized the hyperglycemic response to Ni(II). Concentrations of endogenous immunoreactive insulin in serum were increased from 0.5 to 3 hr after injection of Ni(II) in dosage of 68 μmol/kg. Adrenergic blockade with phentolamine and propranolol did not affect the hyperglycemic response to Ni(II). The hyperglycemic responses to Ni(II), Co(II), and glucagon were greatly suppressed but were not completely prevented by adrenalectomy or by hypophysectomy. These findings are attributed to interruption of the permissive actions of glucocorticoids upon hepatic gluconeogenesis and glycogenolysis." @default.
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- W2009814713 date "1975-05-01" @default.
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- W2009814713 title "Effects of Ni(II), other divalent metal ions, and glucagon upon plasma glucose concentrations in normal, adrenalectomized and hypophysectomized rats" @default.
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- W2009814713 doi "https://doi.org/10.1016/0041-008x(75)90222-7" @default.
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