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- W2009828722 abstract "Only a very limited number of clinical studies have been reported on the measurement of endothelial permeability to hydrophilic solutes (molecular weight less than 6000 Daltons) that normally gain free access to the extravascular space. Because of high extraction efficiencies into the extravascular space, the transfer rates of small solutes of molecular weight about 500 Daltons, like 99Tcm DTPA, are perfusion-dependent as well as diffusion-dependent. We describe non-invasive techniques for measurement of clearance and extraction fraction of 99Tcm DTPA into the extravascular space of the resting forearm using a scintillation probe, from which we then calculated permeability surface area (PS) product. Our values for extraction fraction of about 0.5 and for PS product of about 3 ml per minute per 100 ml tissue are comparable to the values reported in the literature for resting skeletal muscle using more invasive techniques." @default.
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- W2009828722 date "1992-09-01" @default.
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- W2009828722 title "Non-invasive techniques for the measurement of extraction fraction and permeability surface area product of99TcmDTPA in the human forearm" @default.
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- W2009828722 doi "https://doi.org/10.1088/0031-9155/37/9/003" @default.
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