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• W2009839072 abstract "Mycobacterium tuberculosis shikimate dehydrogenase (MtbSD) catalyzes the forth reaction in the shikimate pathway. Here we describe production of K69A, K69H, K69I, K69Q, D105A, and D105N mutant proteins. Screening of several conditions was performed to optimize MtbSD production yield, and an improved purification protocol to obtain homogeneous MtbSD is presented. The rational design of new antitubercular drugs hinges on the availability of M. tuberculosis proteins. Our results show that optimization of expression, disruption, and purification protocols resulted in a higher yield of functional MtbSD enzyme." @default.
• W2009839072 created "2016-06-24" @default.
• W2009839072 creator A5038318918 @default.
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• W2009839072 date "2009-08-01" @default.
• W2009839072 modified "2023-09-26" @default.
• W2009839072 title "Homogeneous recombinant Mycobacterium tuberculosis shikimate dehydrogenase production: An essential step towards target-based drug design" @default.
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• W2009839072 doi "https://doi.org/10.1016/j.ijbiomac.2009.05.003" @default.
• W2009839072 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19463851" @default.
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