FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009849089> ?p ?o ?g. }

• W2009849089 endingPage "675" @default.
• W2009849089 startingPage "667" @default.
• W2009849089 abstract "1 Here we have characterized Ca2+ currents in rat subfornical organ neurones, and their modulation by angiotensin II. Currents were of the high voltage-activated (HNA) subtype, as the threshold for activation was near −30 mV (mid-point potential (V50) of activation −14 mV). Using Ba2+ as the charge carrier, little inactivation was observed, and it occurred only at depolarized potentials (V50 of inactivation −12 mV). More inactivation was observed using Ca2+ as the charge carrier, indicating that Ca2+-dependent inactivation plays a role in regulating Ca2+ channel function in subfornical organ (SFO) neurones. 2 The net Ba2+ current could be blocked by Cd2+ (EC50 1.6 μm), confirming that currents are of the HVA variety. By using selective antagonists, we identified the presence of both L- and N-type channels; 20 μm nifedipine blocked 22 ± 1 % of the current, while ω-conotoxin GVIA blocked 65 ± 7 %, indicating that these currents make up the net current through Ca2+ channels. 3 Angiotensin II potentiated the inward current throughout the range of activation. Using depolarizing voltage ramps, 1 nm angiotensin potentiated the peak current by 14 ± 5 %. We then used selective blockade of the HVA component currents; 20 μm nifedipine failed to prevent the potentiation by angiotensin II (12 ± 5 %), while blocking N-type channels with ω-conotoxin GVIA blocked the facilitation by ANG (2.3 ± 2 %). Losartan (1 μm) prevented the actions of ANG on the inward current (1.6 ± 1 %), indicating that the selective effects of ANG on N-type channels in SFO neurones are mediated by AT1 receptors." @default.
• W2009849089 created "2016-06-24" @default.
• W2009849089 creator A5045866756 @default.
• W2009849089 creator A5056272156 @default.
• W2009849089 date "2001-11-01" @default.
• W2009849089 modified "2023-10-18" @default.
• W2009849089 title "Selective potentiation of N‐type calcium channels by angiotensin II in rat subfornical organ neurones" @default.
• W2009849089 cites W1514673848 @default.
• W2009849089 cites W1628979938 @default.
• W2009849089 cites W1639584526 @default.
• W2009849089 cites W1964632025 @default.
• W2009849089 cites W1981395898 @default.
• W2009849089 cites W1985625400 @default.
• W2009849089 cites W1985908862 @default.
• W2009849089 cites W1997081092 @default.
• W2009849089 cites W1997782840 @default.
• W2009849089 cites W2005843269 @default.
• W2009849089 cites W2006954000 @default.
• W2009849089 cites W2008530471 @default.
• W2009849089 cites W2009588183 @default.
• W2009849089 cites W2020629162 @default.
• W2009849089 cites W2033780986 @default.
• W2009849089 cites W2040691279 @default.
• W2009849089 cites W2042571427 @default.
• W2009849089 cites W2044219020 @default.
• W2009849089 cites W2045825904 @default.
• W2009849089 cites W2053067816 @default.
• W2009849089 cites W2058447299 @default.
• W2009849089 cites W2066707647 @default.
• W2009849089 cites W2069260575 @default.
• W2009849089 cites W2071424576 @default.
• W2009849089 cites W2071928726 @default.
• W2009849089 cites W2085305565 @default.
• W2009849089 cites W2088736807 @default.
• W2009849089 cites W2094915083 @default.
• W2009849089 cites W2112659765 @default.
• W2009849089 cites W2121559062 @default.
• W2009849089 cites W2125269304 @default.
• W2009849089 cites W2151141256 @default.
• W2009849089 cites W2165618729 @default.
• W2009849089 cites W2259434314 @default.
• W2009849089 cites W2270790135 @default.
• W2009849089 cites W2340800809 @default.
• W2009849089 cites W2417990001 @default.
• W2009849089 cites W4245287891 @default.
• W2009849089 cites W4245997773 @default.
• W2009849089 doi "https://doi.org/10.1111/j.1469-7793.2001.t01-1-00667.x" @default.
• W2009849089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2278897" @default.
• W2009849089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11691863" @default.
• W2009849089 hasPublicationYear "2001" @default.
• W2009849089 type Work @default.
• W2009849089 sameAs 2009849089 @default.
• W2009849089 citedByCount "28" @default.
• W2009849089 countsByYear W20098490892012 @default.
• W2009849089 countsByYear W20098490892013 @default.
• W2009849089 countsByYear W20098490892014 @default.
• W2009849089 countsByYear W20098490892015 @default.
• W2009849089 countsByYear W20098490892018 @default.
• W2009849089 countsByYear W20098490892019 @default.
• W2009849089 countsByYear W20098490892021 @default.
• W2009849089 crossrefType "journal-article" @default.
• W2009849089 hasAuthorship W2009849089A5045866756 @default.
• W2009849089 hasAuthorship W2009849089A5056272156 @default.
• W2009849089 hasBestOaLocation W20098490892 @default.
• W2009849089 hasConcept C123915805 @default.
• W2009849089 hasConcept C12554922 @default.
• W2009849089 hasConcept C126322002 @default.
• W2009849089 hasConcept C134018914 @default.
• W2009849089 hasConcept C170493617 @default.
• W2009849089 hasConcept C178790620 @default.
• W2009849089 hasConcept C181911157 @default.
• W2009849089 hasConcept C185592680 @default.
• W2009849089 hasConcept C18699975 @default.
• W2009849089 hasConcept C25274449 @default.
• W2009849089 hasConcept C2775857624 @default.
• W2009849089 hasConcept C2776823063 @default.
• W2009849089 hasConcept C2779066535 @default.
• W2009849089 hasConcept C2780288358 @default.
• W2009849089 hasConcept C2908929049 @default.
• W2009849089 hasConcept C4141045 @default.
• W2009849089 hasConcept C519063684 @default.
• W2009849089 hasConcept C55493867 @default.
• W2009849089 hasConcept C71924100 @default.
• W2009849089 hasConcept C86803240 @default.
• W2009849089 hasConceptScore W2009849089C123915805 @default.
• W2009849089 hasConceptScore W2009849089C12554922 @default.
• W2009849089 hasConceptScore W2009849089C126322002 @default.
• W2009849089 hasConceptScore W2009849089C134018914 @default.
• W2009849089 hasConceptScore W2009849089C170493617 @default.
• W2009849089 hasConceptScore W2009849089C178790620 @default.
• W2009849089 hasConceptScore W2009849089C181911157 @default.
• W2009849089 hasConceptScore W2009849089C185592680 @default.
• W2009849089 hasConceptScore W2009849089C18699975 @default.
• W2009849089 hasConceptScore W2009849089C25274449 @default.
• W2009849089 hasConceptScore W2009849089C2775857624 @default.
• W2009849089 hasConceptScore W2009849089C2776823063 @default.
• W2009849089 hasConceptScore W2009849089C2779066535 @default.
• W2009849089 hasConceptScore W2009849089C2780288358 @default.

• next