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- W2009849888 abstract "Objective To assess impaired quality of life (QOL) of Korean patients with thyroid eye disease (TED) using the TED-QOL questionnaire, to evaluate the adaptability of the questionnaire, and to assess the correlation between TED-QOL and scales of disease severity. Design Prospective, cross-sectional study. Participants Total of 90 consecutive adult patients with TED and Graves’ disease were included in this study. Methods TED-QOL was translated into Korean and administered to the patients. The results were compared with clinical severity scores (clinical activity score, VISA (vision loss (optic neuropathy); inflammation; strabismus/motility; appearance/exposure) classification, modified NOSPECS (no signs or symptoms; only signs; soft tissue; proptosis; extraocular muscle; cornea; sight loss) score, Gorman diplopia scale, and European Group of Graves’ Orbitopathy Classification). Results Clinical scores indicating inflammation and strabismus in patients with TED were positively correlated with overall and visual function–related QOL (Spearman coefficient 0.21–0.38, p < 0.05). Clinical scores associated with appearance were positively correlated with appearance-related QOL (Spearman coefficient 0.26–0.27, p < 0.05). In multivariate analysis, age, soft-tissue inflammation, motility disorder of modified NOSPECS, and motility disorder of VISA classification had positive correlation with overall and function-related QOL. Sex, soft-tissue inflammation, proptosis of modified NOSPECS, and appearance of VISA classification had correlation with appearance-related QOL. In addition, validity of TED-QOL was proved sufficient based on the outcomes of patient interviews and correlation between the subscales of TED-QOL. Conclusions TED-QOL showed significant correlations with various objective clinical parameters of TED. TED-QOL was a simple and useful tool for rapid evaluation of QOL in daily outpatient clinics, which could be readily translated into different languages to be widely applicable to various populations." @default.
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- W2009849888 date "2014-04-01" @default.
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- W2009849888 title "Evaluation of thyroid eye disease: quality-of-life questionnaire (TED-QOL) in Korean patients" @default.
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- W2009849888 doi "https://doi.org/10.1016/j.jcjo.2013.12.007" @default.
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