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- W2009851978 abstract "Characteristic pathologic changes in chronic obstructive pulmonary disease (COPD) include an increased fractional volume of bronchiolar epithelial cells, fibrous thickening of the airway wall, and luminal inflammatory mucus exudates, which are positively correlated with airflow limitation and disease severity. The mechanisms driving general epithelial expansion, mucous secretory cell hyperplasia, and mucus accumulation must relate to the effects of initial toxic exposures on patterns of epithelial stem and progenitor cell proliferation and differentiation, eventually resulting in a self-perpetuating, and difficult to reverse, cycle of injury and repair. In this review, current concepts in stem cell biology and progenitor-progeny relationships related to COPD are discussed, focusing on the factors, pathways, and mechanisms leading to mucous secretory cell hyperplasia and mucus accumulation in the airways. A better understanding of alterations in airway epithelial phenotype in COPD will provide a logical basis for novel therapeutic approaches." @default.
- W2009851978 created "2016-06-24" @default.
- W2009851978 creator A5049641668 @default.
- W2009851978 date "2006-11-01" @default.
- W2009851978 modified "2023-09-27" @default.
- W2009851978 title "Airway Epithelial Stem Cells and the Pathophysiology of Chronic Obstructive Pulmonary Disease" @default.
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- W2009851978 doi "https://doi.org/10.1513/pats.200605-117sf" @default.
- W2009851978 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2647659" @default.
- W2009851978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17065380" @default.
- W2009851978 hasPublicationYear "2006" @default.