FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009852788> ?p ?o ?g. }

• W2009852788 endingPage "82" @default.
• W2009852788 startingPage "76" @default.
• W2009852788 abstract "Background: Although several therapeutic options are currently available for patients with various cancers, the outcomes are often disappointing and a more effective modality needs to be promptly established. We have been exploring an alternative approach using natural agents and two bioactive mushroom extracts isolated from Phellinus linteus (PL), namely PL-ES and PL-I-ES, were of our interest. As anticancer effects of similar extracts have been reported in several cancers, we investigated whether PL-ES and PL-I-ES might have such anticancer activities on a variety of human cancer cells in vitro . Methods: Ten different types of human cancer cell lines, including three metastatic prostate, bladder, kidney, lung, breast, stomach, liver, and brain cancer cells, were employed and tested with PL-ES or PL-I-ES. Cell growth/viability, exertion of oxidative stress, and induction of apoptosis were assessed by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide) assay, lipid peroxidation (LPO) assay, and specific enzymatic assay, respectively. Results: PL-ES (100 µg/mL) exhibited potent anticancer activity, resulting in a significant (40-80%) growth reduction in all 10 cancer cells at 72 hours. PL-I-ES (100 µg/mL) was effective on only four cancer cells but its higher concentration at 250 µg/mL led to a significant (25-90%) growth reduction in seven cancer cells. LPO assays indicated that such a significant growth reduction by PL-ES (100 µg/mL) or PL-I-ES (100 or 250 µg/mL) could result from cell death due to a cytotoxic effect of oxidative stress (through free radicals). Moreover, enzymatic assays for caspase-3 (Csp-3) and caspase-9 (Csp-9), the pro-apoptotic regulators, showed that both enzymes were significantly activated by PL-ES or PL-I-ES, indicating that cell death due to oxidative stress was more likely associated with apoptosis. Conclusions: The present study shows that both PL-ES and PL-I-ES indeed have anticancer effects on a variety of cancer cells, although PL-ES appears to be more potent than PL-I-ES. Such an anticancer effect is presumably attributed to oxidative stress, which will ultimately lead to apoptosis. Therefore, these two bioactive mushroom extracts may have clinical implications in a more effective therapeutic option for a variety of human malignancies. J Clin Med Res. 2015;7(2):76-82 doi: http://dx.doi.org/10.14740/jocmr1996w" @default.
• W2009852788 created "2016-06-24" @default.
• W2009852788 creator A5000629089 @default.
• W2009852788 creator A5003215868 @default.
• W2009852788 creator A5049686252 @default.
• W2009852788 creator A5072214160 @default.
• W2009852788 creator A5077129222 @default.
• W2009852788 date "2015-01-01" @default.
• W2009852788 modified "2023-09-29" @default.
• W2009852788 title "Potent Anticancer Effects of Bioactive Mushroom Extracts (<i>Phellinus linteus</i>) on a Variety of Human Cancer Cells" @default.
• W2009852788 cites W120346798 @default.
• W2009852788 cites W1517347000 @default.
• W2009852788 cites W181281151 @default.
• W2009852788 cites W1964413925 @default.
• W2009852788 cites W1968787111 @default.
• W2009852788 cites W1987396009 @default.
• W2009852788 cites W2005003084 @default.
• W2009852788 cites W2013662959 @default.
• W2009852788 cites W2020713814 @default.
• W2009852788 cites W2041881143 @default.
• W2009852788 cites W2046105274 @default.
• W2009852788 cites W2046112813 @default.
• W2009852788 cites W2057547052 @default.
• W2009852788 cites W2075696680 @default.
• W2009852788 cites W2080029367 @default.
• W2009852788 cites W2090725859 @default.
• W2009852788 cites W2094909143 @default.
• W2009852788 cites W2106787323 @default.
• W2009852788 cites W2139809689 @default.
• W2009852788 cites W2164248036 @default.
• W2009852788 cites W4211118805 @default.
• W2009852788 cites W4232914613 @default.
• W2009852788 doi "https://doi.org/10.14740/jocmr1996w" @default.
• W2009852788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4245057" @default.
• W2009852788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25436023" @default.
• W2009852788 hasPublicationYear "2015" @default.
• W2009852788 type Work @default.
• W2009852788 sameAs 2009852788 @default.
• W2009852788 citedByCount "31" @default.
• W2009852788 countsByYear W20098527882015 @default.
• W2009852788 countsByYear W20098527882016 @default.
• W2009852788 countsByYear W20098527882017 @default.
• W2009852788 countsByYear W20098527882018 @default.
• W2009852788 countsByYear W20098527882019 @default.
• W2009852788 countsByYear W20098527882020 @default.
• W2009852788 countsByYear W20098527882021 @default.
• W2009852788 countsByYear W20098527882022 @default.
• W2009852788 countsByYear W20098527882023 @default.
• W2009852788 crossrefType "journal-article" @default.
• W2009852788 hasAuthorship W2009852788A5000629089 @default.
• W2009852788 hasAuthorship W2009852788A5003215868 @default.
• W2009852788 hasAuthorship W2009852788A5049686252 @default.
• W2009852788 hasAuthorship W2009852788A5072214160 @default.
• W2009852788 hasAuthorship W2009852788A5077129222 @default.
• W2009852788 hasBestOaLocation W20098527881 @default.
• W2009852788 hasConcept C121608353 @default.
• W2009852788 hasConcept C126322002 @default.
• W2009852788 hasConcept C133479454 @default.
• W2009852788 hasConcept C154317977 @default.
• W2009852788 hasConcept C190283241 @default.
• W2009852788 hasConcept C202751555 @default.
• W2009852788 hasConcept C2776151105 @default.
• W2009852788 hasConcept C2778326925 @default.
• W2009852788 hasConcept C2779707156 @default.
• W2009852788 hasConcept C2780783641 @default.
• W2009852788 hasConcept C502942594 @default.
• W2009852788 hasConcept C53227056 @default.
• W2009852788 hasConcept C55493867 @default.
• W2009852788 hasConcept C59822182 @default.
• W2009852788 hasConcept C71924100 @default.
• W2009852788 hasConcept C86803240 @default.
• W2009852788 hasConcept C96232424 @default.
• W2009852788 hasConcept C98274493 @default.
• W2009852788 hasConceptScore W2009852788C121608353 @default.
• W2009852788 hasConceptScore W2009852788C126322002 @default.
• W2009852788 hasConceptScore W2009852788C133479454 @default.
• W2009852788 hasConceptScore W2009852788C154317977 @default.
• W2009852788 hasConceptScore W2009852788C190283241 @default.
• W2009852788 hasConceptScore W2009852788C202751555 @default.
• W2009852788 hasConceptScore W2009852788C2776151105 @default.
• W2009852788 hasConceptScore W2009852788C2778326925 @default.
• W2009852788 hasConceptScore W2009852788C2779707156 @default.
• W2009852788 hasConceptScore W2009852788C2780783641 @default.
• W2009852788 hasConceptScore W2009852788C502942594 @default.
• W2009852788 hasConceptScore W2009852788C53227056 @default.
• W2009852788 hasConceptScore W2009852788C55493867 @default.
• W2009852788 hasConceptScore W2009852788C59822182 @default.
• W2009852788 hasConceptScore W2009852788C71924100 @default.
• W2009852788 hasConceptScore W2009852788C86803240 @default.
• W2009852788 hasConceptScore W2009852788C96232424 @default.
• W2009852788 hasConceptScore W2009852788C98274493 @default.
• W2009852788 hasIssue "2" @default.
• W2009852788 hasLocation W20098527881 @default.
• W2009852788 hasLocation W20098527882 @default.
• W2009852788 hasLocation W20098527883 @default.
• W2009852788 hasLocation W20098527884 @default.
• W2009852788 hasLocation W20098527885 @default.
• W2009852788 hasOpenAccess W2009852788 @default.

• next