FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009854023> ?p ?o ?g. }

• W2009854023 endingPage "9151" @default.
• W2009854023 startingPage "9140" @default.
• W2009854023 abstract "GAGA is a Drosophila transcription factor that shows a high degree of post-translational modification. Here, we show that GAGA factor is acetylated in vivo. Lysine residues K325 and K373 on basic regions BR1 and BR3 of the DNA binding domain, respectively, are shown to be acetylated by PCAF. While BR1 is strictly required to stabilize DNA binding, BR3 is dispensable. However, acetylation of both lysine residues, either alone or in combination, weakens the binding to DNA. Despite the high degree of conservation of K325 and K373 in flies, their mutation to glutamine does not affect DNA binding. Molecular dynamics simulations, using acetylated K325 and a K325Q mutant of GAGA DNA binding domain in complex with DNA, are fully consistent with these results and provide a thermodynamic explanation for this observation. We propose that while K325 and K373 are not essential for DNA binding they have been largely conserved for regulatory purposes, thus highlighting a key regulatory system for GAGA factor in flies." @default.
• W2009854023 created "2016-06-24" @default.
• W2009854023 creator A5009783345 @default.
• W2009854023 creator A5018948227 @default.
• W2009854023 creator A5029739793 @default.
• W2009854023 creator A5035036174 @default.
• W2009854023 creator A5052186995 @default.
• W2009854023 creator A5063534672 @default.
• W2009854023 creator A5089586571 @default.
• W2009854023 date "2010-10-05" @default.
• W2009854023 modified "2023-10-09" @default.
• W2009854023 title "Acetylation of GAGA Factor Modulates Its Interaction with DNA" @default.
• W2009854023 cites W1635667563 @default.
• W2009854023 cites W1974426680 @default.
• W2009854023 cites W1974890383 @default.
• W2009854023 cites W1975580333 @default.
• W2009854023 cites W1976161355 @default.
• W2009854023 cites W1978992130 @default.
• W2009854023 cites W1987477846 @default.
• W2009854023 cites W1995111407 @default.
• W2009854023 cites W2002698073 @default.
• W2009854023 cites W2009826707 @default.
• W2009854023 cites W2010108246 @default.
• W2009854023 cites W2013754949 @default.
• W2009854023 cites W2015688756 @default.
• W2009854023 cites W2025722611 @default.
• W2009854023 cites W2037626623 @default.
• W2009854023 cites W2045494087 @default.
• W2009854023 cites W2047393064 @default.
• W2009854023 cites W2050039524 @default.
• W2009854023 cites W2064025098 @default.
• W2009854023 cites W2067174909 @default.
• W2009854023 cites W2069036961 @default.
• W2009854023 cites W2075369230 @default.
• W2009854023 cites W2077903723 @default.
• W2009854023 cites W2079631023 @default.
• W2009854023 cites W2082541302 @default.
• W2009854023 cites W2083345044 @default.
• W2009854023 cites W2085380563 @default.
• W2009854023 cites W2094807579 @default.
• W2009854023 cites W2098504555 @default.
• W2009854023 cites W2100633106 @default.
• W2009854023 cites W2105746752 @default.
• W2009854023 cites W2106140689 @default.
• W2009854023 cites W2107895168 @default.
• W2009854023 cites W2108826832 @default.
• W2009854023 cites W2109014236 @default.
• W2009854023 cites W2112551809 @default.
• W2009854023 cites W2118913377 @default.
• W2009854023 cites W2121645754 @default.
• W2009854023 cites W2122199548 @default.
• W2009854023 cites W2149263899 @default.
• W2009854023 cites W2153011084 @default.
• W2009854023 doi "https://doi.org/10.1021/bi1004427" @default.
• W2009854023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20849112" @default.
• W2009854023 hasPublicationYear "2010" @default.
• W2009854023 type Work @default.
• W2009854023 sameAs 2009854023 @default.
• W2009854023 citedByCount "8" @default.
• W2009854023 countsByYear W20098540232012 @default.
• W2009854023 countsByYear W20098540232013 @default.
• W2009854023 countsByYear W20098540232017 @default.
• W2009854023 countsByYear W20098540232021 @default.
• W2009854023 countsByYear W20098540232022 @default.
• W2009854023 countsByYear W20098540232023 @default.
• W2009854023 crossrefType "journal-article" @default.
• W2009854023 hasAuthorship W2009854023A5009783345 @default.
• W2009854023 hasAuthorship W2009854023A5018948227 @default.
• W2009854023 hasAuthorship W2009854023A5029739793 @default.
• W2009854023 hasAuthorship W2009854023A5035036174 @default.
• W2009854023 hasAuthorship W2009854023A5052186995 @default.
• W2009854023 hasAuthorship W2009854023A5063534672 @default.
• W2009854023 hasAuthorship W2009854023A5089586571 @default.
• W2009854023 hasConcept C101762097 @default.
• W2009854023 hasConcept C104317684 @default.
• W2009854023 hasConcept C107824862 @default.
• W2009854023 hasConcept C119157956 @default.
• W2009854023 hasConcept C143065580 @default.
• W2009854023 hasConcept C150194340 @default.
• W2009854023 hasConcept C185592680 @default.
• W2009854023 hasConcept C25166345 @default.
• W2009854023 hasConcept C2776016237 @default.
• W2009854023 hasConcept C33987129 @default.
• W2009854023 hasConcept C3662595 @default.
• W2009854023 hasConcept C515207424 @default.
• W2009854023 hasConcept C5179208 @default.
• W2009854023 hasConcept C552990157 @default.
• W2009854023 hasConcept C55493867 @default.
• W2009854023 hasConcept C86339819 @default.
• W2009854023 hasConcept C86803240 @default.
• W2009854023 hasConcept C94966510 @default.
• W2009854023 hasConcept C95444343 @default.
• W2009854023 hasConceptScore W2009854023C101762097 @default.
• W2009854023 hasConceptScore W2009854023C104317684 @default.
• W2009854023 hasConceptScore W2009854023C107824862 @default.
• W2009854023 hasConceptScore W2009854023C119157956 @default.
• W2009854023 hasConceptScore W2009854023C143065580 @default.
• W2009854023 hasConceptScore W2009854023C150194340 @default.

• next