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- W2009859966 abstract "A model for narcolepsy is developed on the basis of data obtained from brains collected at post mortem from three patients with narcolepsy. The concentration of dopamine, noradrenaline, and serotonin and their metabolites was measured in many brain regions. The number and affinity of the 3-H-spiperone and 3-H-prazocin binding sites was also measured in many of these regions to characterize the D-2 dopamine and alpha-1-noradrenergic receptors, respectively. Evidence for significantly increased serotonin levels and serotonin turnover was found in many brain regions. Noradrenaline turnover was increased in the frontal cortex. DOPAC/DA was significantly reduced in the striatum. The number of D-2 dopamine receptors, however, was markedly increased in this region. The number of alpha-1-noradrenergic receptors was significantly decreased in the frontal cortex and amygdala. Our neurochemical data demonstrating increased NA and 5-HT turnover suggest that locus coeruleus noradrenergic neurones and raphe serotonergic neurones are overactive in narcolepsy. Current evidence posits that increased activity in these neurones depresses the activity of cholinergic pedunculopontine (PP) REM sleep effector neurones. PP neurones project to and stimulate the dopaminergic substantia nigra compacta neurones. Decreased PP activity in narcolepsy, thus, could lead to pontine cholinergic supersensitivity and could also reduce the firing rates of dopaminergic neurones, as the low striatal ratio of DOPAC/DA suggests. An increase in the number of D-2 dopamine receptors in the striatum may result. The reason for the increased activity of the noradrenergic and serotonergic neurones remains to be determined, but immune inactivation of alpha-1-noradrenergic receptors may be the initiating event. Low alpha-1-noradrenergic receptor numbers may account for the chronic drowsiness of narcolepsy. The repeated entry into sleep, and into REM sleep in particular, may represent a homeostatic response to increase these receptor numbers and, thus, to increase alertness. Some therapeutic implications of this model are presented in the discussion." @default.
- W2009859966 created "2016-06-24" @default.
- W2009859966 creator A5006740382 @default.
- W2009859966 date "1991-06-01" @default.
- W2009859966 modified "2023-09-27" @default.
- W2009859966 title "A model for narcolepsy." @default.
- W2009859966 cites W133853766 @default.
- W2009859966 cites W140119246 @default.
- W2009859966 cites W1483439847 @default.
- W2009859966 cites W1517107662 @default.
- W2009859966 cites W1521227715 @default.
- W2009859966 cites W1521916566 @default.
- W2009859966 cites W1523941569 @default.
- W2009859966 cites W1882131888 @default.
- W2009859966 cites W1892094001 @default.
- W2009859966 cites W193039664 @default.
- W2009859966 cites W1967043913 @default.
- W2009859966 cites W1970164512 @default.
- W2009859966 cites W1974703596 @default.
- W2009859966 cites W1977690251 @default.
- W2009859966 cites W1978363362 @default.
- W2009859966 cites W1978378245 @default.
- W2009859966 cites W1984642996 @default.
- W2009859966 cites W1987778679 @default.
- W2009859966 cites W1988003217 @default.
- W2009859966 cites W1989485566 @default.
- W2009859966 cites W1990989480 @default.
- W2009859966 cites W1992160748 @default.
- W2009859966 cites W1993072889 @default.
- W2009859966 cites W1995858124 @default.
- W2009859966 cites W1997065612 @default.
- W2009859966 cites W1999580747 @default.
- W2009859966 cites W2005959034 @default.
- W2009859966 cites W2006051132 @default.
- W2009859966 cites W2006171178 @default.
- W2009859966 cites W2009977950 @default.
- W2009859966 cites W2011808456 @default.
- W2009859966 cites W2014551034 @default.
- W2009859966 cites W2019574836 @default.
- W2009859966 cites W2020164120 @default.
- W2009859966 cites W2022260697 @default.
- W2009859966 cites W2023119138 @default.
- W2009859966 cites W2026940382 @default.
- W2009859966 cites W2027086358 @default.
- W2009859966 cites W2028753581 @default.
- W2009859966 cites W2038003772 @default.
- W2009859966 cites W2038240048 @default.
- W2009859966 cites W2038291091 @default.
- W2009859966 cites W2038560671 @default.
- W2009859966 cites W2041352701 @default.
- W2009859966 cites W2045410682 @default.
- W2009859966 cites W2045960912 @default.
- W2009859966 cites W2046957687 @default.
- W2009859966 cites W2048970158 @default.
- W2009859966 cites W2049139864 @default.
- W2009859966 cites W2049338999 @default.
- W2009859966 cites W2053286463 @default.
- W2009859966 cites W2053738008 @default.
- W2009859966 cites W2054547728 @default.
- W2009859966 cites W2057735701 @default.
- W2009859966 cites W2061230186 @default.
- W2009859966 cites W2066596057 @default.
- W2009859966 cites W2069776267 @default.
- W2009859966 cites W2072830463 @default.
- W2009859966 cites W2073274241 @default.
- W2009859966 cites W2074528693 @default.
- W2009859966 cites W2075596256 @default.
- W2009859966 cites W2077340848 @default.
- W2009859966 cites W2078142993 @default.
- W2009859966 cites W2078725934 @default.
- W2009859966 cites W2079058594 @default.
- W2009859966 cites W2082212180 @default.
- W2009859966 cites W2086145701 @default.
- W2009859966 cites W2086255861 @default.
- W2009859966 cites W2088007780 @default.
- W2009859966 cites W2088048961 @default.
- W2009859966 cites W2089224734 @default.
- W2009859966 cites W2089424511 @default.
- W2009859966 cites W2089920562 @default.
- W2009859966 cites W2091092652 @default.
- W2009859966 cites W2091680463 @default.
- W2009859966 cites W2092491301 @default.
- W2009859966 cites W2094316274 @default.
- W2009859966 cites W2107009511 @default.
- W2009859966 cites W2107728240 @default.
- W2009859966 cites W2111670596 @default.
- W2009859966 cites W2112910402 @default.
- W2009859966 cites W2129174488 @default.
- W2009859966 cites W2140506688 @default.
- W2009859966 cites W2145580969 @default.
- W2009859966 cites W2156426890 @default.
- W2009859966 cites W2162774153 @default.
- W2009859966 cites W2164153190 @default.
- W2009859966 cites W2175259048 @default.
- W2009859966 cites W2264106490 @default.
- W2009859966 cites W2272930841 @default.
- W2009859966 cites W2285705032 @default.
- W2009859966 cites W2313877543 @default.