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• W2009861234 abstract "El uso de estatinas se asocia a una reducción de accidentes coronarios en prevención primaria y secundaria y después de angioplastia primaria. Investigar si el empleo de estatinas en pacientes sometidos a cirugía de revascularización coronaria (CRC) se asocia a beneficio clínico. Se incluyeron 102 pacientes consecutivos con enfermedad coronaria para CRC electiva y aislada. En el momento de la inclusión se registró el tratamiento preoperatorio y las variables clínicas basales. En el seguimiento se registró la aparición de muerte de origen cardíaco e infarto agudo de miocardio (IAM) en los primeros 30 días. Recibían estatinas 61 pacientes (60%) frente a 41 (40%) que no las recibían. No se encontraron diferencias significativas entre ambas poblaciones respecto a las características basales. A los 30 días se produjo una muerte cardíaca (1,6%) en el grupo que recibió estatinas, frente a cinco (12,2%) en el grupo que no las recibían (p = 0,02), el IAM ocurrió en cuatro (6,6%) frente a 8 (19,5%) (p = 0,04) y el resultado compuesto de muerte cardíaca o IAM ocurrió en cinco (8,2%) frente a 10 (24,4%) (p = 0,02). En un modelo multivariado, el tratamiento preoperatorio con estatinas se mantuvo como un factor independiente de predicción (p = 0,01; odds ratio [OR]: 3,6) de la aparición de muerte de causa cardíaca o IAM durante los primeros 30 días después de la intervención. El tratamiento previo con estatinas se asocia de forma significativa e independiente a un menor riesgo de IAM o muerte de origen cardíaco en pacientes sometidos a CRC. Statin treatment diminishes adverse cardiac events both in primary and secondary prevention and also after percutaneous coronary intervention. To study if preoperative statin treatment is associated with any clinical advantage after coronary artery surgery. We enrolled 102 consecutive patients with coronary artery disease, scheduled for elective coronary artery surgery. Combined procedures were excluded. Preoperative treatment and the clinical baseline characteristics were recorded in all patients at inclusion. Cardiac death and acute myocardial infarction (AMI) were recorded during the first 30 days. Sixty one patients (60%) were on preoperative statin treatment vs. 41 (40%) who were not. There were no differences at baseline level between both groups. There was one cardiac death at 30 days (1.6%) in the statin-treatment group vs. five deaths (12.2%) in the nostatin group (p = 0.02). Acute myocardial infarction presented in four (6.6%) vs. eight (19.5%) (p = 0.04). The primary combined cardiac endpoint made of cardiac death or AMI occurred in five (8.2%) vs. 10 (24.4%) (p = 0.02). In a multivariate model, preoperative statin treatment remained an independent predictor (p = 0.01; odds ratio [OR] 3.6) of cardiac death or AMI during the first 30 days after surgery. Preoperative statin-treatment was significative and independently associated with less risk of AMI or cardiath death in patients who underwent coronary artery bypass grafting." @default.
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• W2009861234 date "2005-04-01" @default.
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• W2009861234 title "Efecto del tratamiento preoperatorio con estatinas sobre los resultados de la cirugía coronaria" @default.
• W2009861234 doi "https://doi.org/10.1016/s1134-0096(05)70372-7" @default.
• W2009861234 hasPublicationYear "2005" @default.
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