FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009862783> ?p ?o ?g. }

• W2009862783 endingPage "1856" @default.
• W2009862783 startingPage "1848" @default.
• W2009862783 abstract "Abstract Context: In animals, peroxisome proliferator-activated receptor-α (PPARα) and PPARγ agonists down-regulate 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) mRNA and activity in liver and adipose tissue, respectively, and PPARγ agonists reduce ACTH secretion from corticotrope cells. Objective: Our objective was to test whether PPAR agonists alter cortisol secretion and peripheral regeneration by 11β-HSD1 in humans and whether reduced cortisol action contributes to metabolic effects of PPARγ agonists. Design and Setting: Three randomized placebo-controlled crossover studies were conducted at a clinical research facility. Patients and Participants: Healthy men and patients with type 2 diabetes participated. Interventions, Outcome Measures, and Results: In nine healthy men, 7 d of PPARα agonist (fenofibrate) or PPARγ agonist (rosiglitazone) had no effect on cortisol secretion, hepatic cortisol generation after oral cortisone administration, or tracer kinetics during 9,11,12,12-[2H]4-cortisol infusion, although rosiglitazone marginally reduced cortisol generation in sc adipose tissue measured by in vivo microdialysis. In 12 healthy men, 4–5 wk of rosiglitazone increased insulin sensitivity during insulin infusion but did not change 11β-HSD1 mRNA or activity in sc adipose tissue, and insulin sensitization was unaffected by glucocorticoid blockade with a combination of metyrapone and RU38486. In 12 men with type 2 diabetes 12 wk of rosiglitazone reduced arteriovenous cortisone extraction across abdominal sc adipose tissue and reduced 11β-HSD1 mRNA in sc adipose tissue but increased plasma cortisol concentrations. Conclusions: Neither PPARα nor PPARγ agonists down-regulate 11β-HSD1 or cortisol secretion acutely in humans. The early insulin-sensitizing effect of rosiglitazone is not dependent on reducing intracellular glucocorticoid concentrations. Reduced adipose 11β-HSD1 expression and increased plasma cortisol during longer therapy with rosiglitazone probably reflect indirect effects, e.g. mediated by changes in body fat." @default.
• W2009862783 created "2016-06-24" @default.
• W2009862783 creator A5014052426 @default.
• W2009862783 creator A5017724906 @default.
• W2009862783 creator A5018893535 @default.
• W2009862783 creator A5021328490 @default.
• W2009862783 creator A5046153343 @default.
• W2009862783 creator A5055458600 @default.
• W2009862783 creator A5061345698 @default.
• W2009862783 date "2007-05-01" @default.
• W2009862783 modified "2023-09-26" @default.
• W2009862783 title "Effects of Peroxisome Proliferator-Activated Receptor-α and -γ Agonists on 11β-Hydroxysteroid Dehydrogenase Type 1 in Subcutaneous Adipose Tissue in Men" @default.
• W2009862783 cites W1965284228 @default.
• W2009862783 cites W1969228078 @default.
• W2009862783 cites W1984519453 @default.
• W2009862783 cites W1985776330 @default.
• W2009862783 cites W1990179580 @default.
• W2009862783 cites W1995037562 @default.
• W2009862783 cites W1995290986 @default.
• W2009862783 cites W1998389276 @default.
• W2009862783 cites W1999530745 @default.
• W2009862783 cites W2016125985 @default.
• W2009862783 cites W2021943148 @default.
• W2009862783 cites W2038654926 @default.
• W2009862783 cites W2041297104 @default.
• W2009862783 cites W2061835132 @default.
• W2009862783 cites W2061988825 @default.
• W2009862783 cites W2065323334 @default.
• W2009862783 cites W2065532093 @default.
• W2009862783 cites W2073417824 @default.
• W2009862783 cites W2074599622 @default.
• W2009862783 cites W2086635975 @default.
• W2009862783 cites W2092020543 @default.
• W2009862783 cites W2092463003 @default.
• W2009862783 cites W2098274706 @default.
• W2009862783 cites W2100159933 @default.
• W2009862783 cites W2105820409 @default.
• W2009862783 cites W2109095584 @default.
• W2009862783 cites W2115414014 @default.
• W2009862783 cites W2116553454 @default.
• W2009862783 cites W2123255057 @default.
• W2009862783 cites W2123595943 @default.
• W2009862783 cites W2123631984 @default.
• W2009862783 cites W2131431703 @default.
• W2009862783 cites W2138296752 @default.
• W2009862783 cites W2150925908 @default.
• W2009862783 cites W2164058090 @default.
• W2009862783 cites W2165019512 @default.
• W2009862783 doi "https://doi.org/10.1210/jc.2006-2713" @default.
• W2009862783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17327378" @default.
• W2009862783 hasPublicationYear "2007" @default.
• W2009862783 type Work @default.
• W2009862783 sameAs 2009862783 @default.
• W2009862783 citedByCount "39" @default.
• W2009862783 countsByYear W20098627832012 @default.
• W2009862783 countsByYear W20098627832013 @default.
• W2009862783 countsByYear W20098627832014 @default.
• W2009862783 countsByYear W20098627832015 @default.
• W2009862783 countsByYear W20098627832016 @default.
• W2009862783 countsByYear W20098627832017 @default.
• W2009862783 countsByYear W20098627832019 @default.
• W2009862783 countsByYear W20098627832020 @default.
• W2009862783 countsByYear W20098627832021 @default.
• W2009862783 countsByYear W20098627832022 @default.
• W2009862783 crossrefType "journal-article" @default.
• W2009862783 hasAuthorship W2009862783A5014052426 @default.
• W2009862783 hasAuthorship W2009862783A5017724906 @default.
• W2009862783 hasAuthorship W2009862783A5018893535 @default.
• W2009862783 hasAuthorship W2009862783A5021328490 @default.
• W2009862783 hasAuthorship W2009862783A5046153343 @default.
• W2009862783 hasAuthorship W2009862783A5055458600 @default.
• W2009862783 hasAuthorship W2009862783A5061345698 @default.
• W2009862783 hasBestOaLocation W20098627831 @default.
• W2009862783 hasConcept C126322002 @default.
• W2009862783 hasConcept C134018914 @default.
• W2009862783 hasConcept C166075782 @default.
• W2009862783 hasConcept C170493617 @default.
• W2009862783 hasConcept C171089720 @default.
• W2009862783 hasConcept C181199279 @default.
• W2009862783 hasConcept C187345961 @default.
• W2009862783 hasConcept C2776317432 @default.
• W2009862783 hasConcept C2776923340 @default.
• W2009862783 hasConcept C2777180221 @default.
• W2009862783 hasConcept C2777391703 @default.
• W2009862783 hasConcept C2779306644 @default.
• W2009862783 hasConcept C2780152017 @default.
• W2009862783 hasConcept C55493867 @default.
• W2009862783 hasConcept C555293320 @default.
• W2009862783 hasConcept C71924100 @default.
• W2009862783 hasConcept C86803240 @default.
• W2009862783 hasConceptScore W2009862783C126322002 @default.
• W2009862783 hasConceptScore W2009862783C134018914 @default.
• W2009862783 hasConceptScore W2009862783C166075782 @default.
• W2009862783 hasConceptScore W2009862783C170493617 @default.
• W2009862783 hasConceptScore W2009862783C171089720 @default.
• W2009862783 hasConceptScore W2009862783C181199279 @default.
• W2009862783 hasConceptScore W2009862783C187345961 @default.
• W2009862783 hasConceptScore W2009862783C2776317432 @default.

• next