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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009885803> ?p ?o ?g. }

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• W2009885803 abstract "Previous studies have shown that Delta-mediated Notch signaling regulates the number of early differentiating neurons. However, the role of Notch activation and Jagged-mediated signaling during late neurogenesis remains poorly defined. In the developing spinal cord of zebrafish, GABAergic Kolmer-Agduhr (KA'') cells and motor neurons (MN) emerge sequentially from their progenitors in the p3 domain. Jagged2 is expressed uniformly in the pMN domain during late neurogenesis where Olig2 is required for its expression. We suggest that Jagged2 interacts ventrally with progenitors in the adjacent p3 domain, where it has a critical role in the maintenance of proliferating neural progenitors and in preventing differentiation of these progenitors as GABAergic KA'' cells or secondary MN. This study identifies a critical role for Jagged-Notch signaling in the maintenance of proliferating neural precursors in a discrete compartment of the neural tube during the continuing growth and development of the vertebrate nervous system." @default.
• W2009885803 created "2016-06-24" @default.
• W2009885803 creator A5024881689 @default.
• W2009885803 creator A5065315410 @default.
• W2009885803 date "2007-04-03" @default.
• W2009885803 modified "2023-10-16" @default.
• W2009885803 title "Jagged-mediated Notch signaling maintains proliferating neural progenitors and regulates cell diversity in the ventral spinal cord" @default.
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• W2009885803 doi "https://doi.org/10.1073/pnas.0607062104" @default.
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