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• W2009890239 abstract "As part of a project directed toward the discovery of new cancer chemopreventive agents from plants, two new natural products, asparagusic acid anti-S-oxide methyl ester (1) and asparagusic acid syn-S-oxide methyl ester (2), a new acetylenic compound, 2-hydroxyasparenyn {3‘,4‘-trans-2-hydroxy-1-methoxy-4-[5-(4-methoxyphenoxy)-3-penten-1-ynyl]-benzene} (3), as well as eleven known compounds, asparenyn (4), asparenyol (5), (±)-1-monopalmitin (6), ferulic acid (7), 1,3-O-di-p-coumaroylglycerol (8), 1-O-feruloyl-3-O-p-coumaroylglycerol (9), blumenol C, (±)-epipinoresinol, linoleic acid, 1,3-O-diferuloylglycerol, and 1,2-O-diferuloylglycerol, were isolated from an ethyl acetate-soluble fraction of the methanol extract of the aerial parts of Asparagus officinalis (Asparagus), using a bioassay based on the inhibition of cyclooxygenase-2 to monitor chromatographic fractionation. The structures of compounds 1-3 were elucidated by 1D- and 2D-NMR experiments (1H NMR, 13C NMR, DEPT, COSY, HMQC, HMBC and NOESY). All the isolates were evaluated for their inhibitory effects against both cyclooxygenase-1 and -2, with the most active compound being linoleic acid. Keywords: Asparagus officinalis L.; Liliaceae; asparagusic acid anti- and syn-S-oxide methyl esters; 2-hydroxyasparenyn; cyclooxygenase-2; cancer chemoprevention" @default.
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• W2009890239 date "2004-03-19" @default.
• W2009890239 modified "2023-10-02" @default.
• W2009890239 title "Constituents of <i>Asparagus officinalis </i>Evaluated for Inhibitory Activity against Cyclooxygenase-2" @default.
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• W2009890239 doi "https://doi.org/10.1021/jf0305229" @default.
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