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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009898502> ?p ?o ?g. }

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• W2009898502 abstract "The N-end rule is one ubiquitin-proteolytic pathway that relates the in vivo half-life of a protein to the identity of its N-terminal residue. NTAN1 deamidates N-terminal asparagine to aspartate, which is conjugated to arginine by ATE1. An N-terminal arginine-bearing substrate protein is recognized, ubiquitylated by UBR1/E3alpha, and subsequently degraded by 26S proteasomes. Previous research showed that NTAN1-deficient mice exhibited impaired long-term memory in the Lashley III maze. Therefore, a series of studies, designed to assess the role of NTAN1 in short- and intermediate-term memory processes, was undertaken. Two hundred sixty mice (126 -/-; 134 +/ +) received Lashley III maze training with intertrial intervals ranging from 2-180 min. Results indicated that inactivation of NTAN1 amidase differentially affects short-, intermediate-, and long-term memory." @default.
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• W2009898502 date "2000-09-01" @default.
• W2009898502 modified "2023-10-16" @default.
• W2009898502 title "Varying Intertrial Interval Reveals Temporally Defined Memory Deficits and Enhancements in NTAN1-Deficient Mice" @default.
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• W2009898502 doi "https://doi.org/10.1101/lm.33500" @default.
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