FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009904927> ?p ?o ?g. }

• W2009904927 endingPage "192" @default.
• W2009904927 startingPage "182" @default.
• W2009904927 abstract "Mutations in Bruton's tyrosine kinase (Btk) cause the B-cell disorder X-linked agammaglobulinaemia (XLA) in humans, but the effect of Btk deficiency in human bone health has not been investigated previously. In this study, we show that human Btk-deficient osteoclasts are defective at resorption activity in vitro owing to a dysregulation of the actin cytoskeletal function. Contrary to expectation, XLA patients did not exhibit increased bone density or alterations in serum markers of bone turnover, indicating that a potential compensation mechanism normalizes bone homeostasis. In contrast to the bone turnover markers, the levels of inflammatory cytokines interleukin 6 (IL-6), IL-1β, and tumor necrosis factor α (TNF-α) were significantly elevated in XLA patients' serum compared with control individuals. Supplementation of osteoclast cultures from normal and XLA subjects with serum from XLA patients or recombinant inflammatory cytokines IL-6, IL-1β, and TNF-α resulted in a stimulation of osteoclast activity in vitro, whereas the addition of cytokine-neutralizing antibodies inhibited this stimulatory effect, confirming that elevated inflammatory cytokines in XLA serum heightened osteoclast activity in vitro. This study provides novel evidence that Btk signaling is crucial for optimal actin cytoskeletal organization and lacunar resorption in isolated osteoclasts. In XLA patients, however, these inherent osteoclast defects are corrected by increased inflammatory cytokine levels, restoring osteoclast activity and leading to the normalization of bone density. © 2011 American Society for Bone and Mineral Research." @default.
• W2009904927 created "2016-06-24" @default.
• W2009904927 creator A5040527564 @default.
• W2009904927 creator A5058026351 @default.
• W2009904927 creator A5067552329 @default.
• W2009904927 creator A5086812364 @default.
• W2009904927 date "2010-12-22" @default.
• W2009904927 modified "2023-10-17" @default.
• W2009904927 title "Elevated cytokine production restores bone resorption by human Btk-deficient osteoclasts" @default.
• W2009904927 cites W1523413388 @default.
• W2009904927 cites W1528508275 @default.
• W2009904927 cites W1538100539 @default.
• W2009904927 cites W1585327912 @default.
• W2009904927 cites W1622426808 @default.
• W2009904927 cites W1768061198 @default.
• W2009904927 cites W1967796318 @default.
• W2009904927 cites W1975505424 @default.
• W2009904927 cites W1975587041 @default.
• W2009904927 cites W1983068219 @default.
• W2009904927 cites W1986979099 @default.
• W2009904927 cites W1994780675 @default.
• W2009904927 cites W1995976925 @default.
• W2009904927 cites W2003164049 @default.
• W2009904927 cites W2007750331 @default.
• W2009904927 cites W2011305717 @default.
• W2009904927 cites W2015127006 @default.
• W2009904927 cites W2019146941 @default.
• W2009904927 cites W2033878750 @default.
• W2009904927 cites W2050104200 @default.
• W2009904927 cites W2059712054 @default.
• W2009904927 cites W2066143619 @default.
• W2009904927 cites W2066521125 @default.
• W2009904927 cites W2068456278 @default.
• W2009904927 cites W2073042614 @default.
• W2009904927 cites W2078384542 @default.
• W2009904927 cites W2084102864 @default.
• W2009904927 cites W2092050919 @default.
• W2009904927 cites W2093349314 @default.
• W2009904927 cites W2093588246 @default.
• W2009904927 cites W2095139297 @default.
• W2009904927 cites W2098839273 @default.
• W2009904927 cites W2103955782 @default.
• W2009904927 cites W2126446849 @default.
• W2009904927 cites W2131357215 @default.
• W2009904927 cites W2132472913 @default.
• W2009904927 cites W2157390376 @default.
• W2009904927 cites W2161697779 @default.
• W2009904927 cites W2161853189 @default.
• W2009904927 cites W2166351899 @default.
• W2009904927 cites W4249950277 @default.
• W2009904927 doi "https://doi.org/10.1002/jbmr.210" @default.
• W2009904927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20715177" @default.
• W2009904927 hasPublicationYear "2010" @default.
• W2009904927 type Work @default.
• W2009904927 sameAs 2009904927 @default.
• W2009904927 citedByCount "39" @default.
• W2009904927 countsByYear W20099049272012 @default.
• W2009904927 countsByYear W20099049272013 @default.
• W2009904927 countsByYear W20099049272014 @default.
• W2009904927 countsByYear W20099049272015 @default.
• W2009904927 countsByYear W20099049272016 @default.
• W2009904927 countsByYear W20099049272017 @default.
• W2009904927 countsByYear W20099049272018 @default.
• W2009904927 countsByYear W20099049272019 @default.
• W2009904927 countsByYear W20099049272020 @default.
• W2009904927 countsByYear W20099049272021 @default.
• W2009904927 countsByYear W20099049272022 @default.
• W2009904927 crossrefType "journal-article" @default.
• W2009904927 hasAuthorship W2009904927A5040527564 @default.
• W2009904927 hasAuthorship W2009904927A5058026351 @default.
• W2009904927 hasAuthorship W2009904927A5067552329 @default.
• W2009904927 hasAuthorship W2009904927A5086812364 @default.
• W2009904927 hasConcept C126322002 @default.
• W2009904927 hasConcept C134018914 @default.
• W2009904927 hasConcept C170493617 @default.
• W2009904927 hasConcept C17991360 @default.
• W2009904927 hasConcept C185592680 @default.
• W2009904927 hasConcept C203014093 @default.
• W2009904927 hasConcept C2776033226 @default.
• W2009904927 hasConcept C2778690821 @default.
• W2009904927 hasConcept C42362537 @default.
• W2009904927 hasConcept C502942594 @default.
• W2009904927 hasConcept C673006 @default.
• W2009904927 hasConcept C71924100 @default.
• W2009904927 hasConcept C90059517 @default.
• W2009904927 hasConceptScore W2009904927C126322002 @default.
• W2009904927 hasConceptScore W2009904927C134018914 @default.
• W2009904927 hasConceptScore W2009904927C170493617 @default.
• W2009904927 hasConceptScore W2009904927C17991360 @default.
• W2009904927 hasConceptScore W2009904927C185592680 @default.
• W2009904927 hasConceptScore W2009904927C203014093 @default.
• W2009904927 hasConceptScore W2009904927C2776033226 @default.
• W2009904927 hasConceptScore W2009904927C2778690821 @default.
• W2009904927 hasConceptScore W2009904927C42362537 @default.
• W2009904927 hasConceptScore W2009904927C502942594 @default.
• W2009904927 hasConceptScore W2009904927C673006 @default.
• W2009904927 hasConceptScore W2009904927C71924100 @default.
• W2009904927 hasConceptScore W2009904927C90059517 @default.

• next