FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2009917811> ?p ?o ?g. }

• W2009917811 abstract "Acute liver injury due to ischemia can occur during several clinical procedures e.g. liver transplantation, hepatic tumor resection or trauma repair and can result in liver failure which has a high mortality rate. Therefore murine studies of hepatic ischemia have become an important field of research by providing the opportunity to utilize pharmacological and genetic studies. Specifically, conditional mice with tissue specific deletion of a gene (cre, flox system) provide insights into the role of proteins in particular tissues. Because of the technical difficulty associated with manually clamping the portal triad in mice, we performed a systematic evaluation using a hanging-weight system for portal triad occlusion which has been previously described. By using a hanging-weight system we place a suture around the left branch of the portal triad without causing any damage to the hepatic lobes, since also the finest clamps available can cause hepatic tissue damage because of the close location of liver tissue to the vessels. Furthermore, the right branch of the hepatic triad is still perfused thus no intestinal congestion occurs with this technique as blood flow to the right hepatic lobes is preserved. Furthermore, the portal triad is only manipulated once throughout the entire surgical procedure. As a result, procedures like pre-conditioning, with short times of ischemia and reperfusion, can be easily performed. Systematic evaluation of this model by performing different ischemia and reperfusion times revealed a close correlation of hepatic ischemia time with liver damage as measured by alanine (ALT) and aspartate (AST) aminotransferase serum levels. Taken together, these studies confirm highly reproducible liver injury when using the hanging-weight system for hepatic ischemia and intermittent reperfusion. Thus, this technique might be useful for other investigators interested in liver ischemia studies in mice. Therefore the video clip provides a detailed step-by-step description of this technique." @default.
• W2009917811 created "2016-06-24" @default.
• W2009917811 creator A5001509341 @default.
• W2009917811 creator A5011458287 @default.
• W2009917811 creator A5034793757 @default.
• W2009917811 creator A5036886545 @default.
• W2009917811 creator A5048822545 @default.
• W2009917811 creator A5082648868 @default.
• W2009917811 date "2012-08-07" @default.
• W2009917811 modified "2023-09-26" @default.
• W2009917811 title "Use of a Hanging-weight System for Liver Ischemia in Mice" @default.
• W2009917811 cites W1968787089 @default.
• W2009917811 cites W1991588322 @default.
• W2009917811 cites W2024203095 @default.
• W2009917811 cites W2030262660 @default.
• W2009917811 cites W2034273217 @default.
• W2009917811 cites W2051078267 @default.
• W2009917811 cites W2054295432 @default.
• W2009917811 cites W2080325411 @default.
• W2009917811 cites W2087098834 @default.
• W2009917811 cites W2109855059 @default.
• W2009917811 cites W2123288021 @default.
• W2009917811 cites W2160766754 @default.
• W2009917811 cites W2410485534 @default.
• W2009917811 doi "https://doi.org/10.3791/2550" @default.
• W2009917811 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3486745" @default.
• W2009917811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22895458" @default.
• W2009917811 hasPublicationYear "2012" @default.
• W2009917811 type Work @default.
• W2009917811 sameAs 2009917811 @default.
• W2009917811 citedByCount "3" @default.
• W2009917811 countsByYear W20099178112015 @default.
• W2009917811 countsByYear W20099178112016 @default.
• W2009917811 countsByYear W20099178112017 @default.
• W2009917811 crossrefType "journal-article" @default.
• W2009917811 hasAuthorship W2009917811A5001509341 @default.
• W2009917811 hasAuthorship W2009917811A5011458287 @default.
• W2009917811 hasAuthorship W2009917811A5034793757 @default.
• W2009917811 hasAuthorship W2009917811A5036886545 @default.
• W2009917811 hasAuthorship W2009917811A5048822545 @default.
• W2009917811 hasAuthorship W2009917811A5082648868 @default.
• W2009917811 hasBestOaLocation W20099178112 @default.
• W2009917811 hasConcept C126322002 @default.
• W2009917811 hasConcept C142724271 @default.
• W2009917811 hasConcept C2779609443 @default.
• W2009917811 hasConcept C2911091166 @default.
• W2009917811 hasConcept C541997718 @default.
• W2009917811 hasConcept C71924100 @default.
• W2009917811 hasConceptScore W2009917811C126322002 @default.
• W2009917811 hasConceptScore W2009917811C142724271 @default.
• W2009917811 hasConceptScore W2009917811C2779609443 @default.
• W2009917811 hasConceptScore W2009917811C2911091166 @default.
• W2009917811 hasConceptScore W2009917811C541997718 @default.
• W2009917811 hasConceptScore W2009917811C71924100 @default.
• W2009917811 hasIssue "66" @default.
• W2009917811 hasLocation W20099178111 @default.
• W2009917811 hasLocation W20099178112 @default.
• W2009917811 hasLocation W20099178113 @default.
• W2009917811 hasLocation W20099178114 @default.
• W2009917811 hasOpenAccess W2009917811 @default.
• W2009917811 hasPrimaryLocation W20099178111 @default.
• W2009917811 hasRelatedWork W2007536964 @default.
• W2009917811 hasRelatedWork W2045805936 @default.
• W2009917811 hasRelatedWork W2372353835 @default.
• W2009917811 hasRelatedWork W2373402090 @default.
• W2009917811 hasRelatedWork W2394372752 @default.
• W2009917811 hasRelatedWork W2431095629 @default.
• W2009917811 hasRelatedWork W2920328101 @default.
• W2009917811 hasRelatedWork W3036143884 @default.
• W2009917811 hasRelatedWork W3048868682 @default.
• W2009917811 hasRelatedWork W4249385634 @default.
• W2009917811 isParatext "false" @default.
• W2009917811 isRetracted "false" @default.
• W2009917811 magId "2009917811" @default.
• W2009917811 workType "article" @default.