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- W2009920503 endingPage "249" @default.
- W2009920503 startingPage "242" @default.
- W2009920503 abstract "Purpose of review Despite decades of advances in prehospital and in-hospital medical care, patients with out-of-hospital cardiac arrest continue to have poor neurologic and cardiac function following otherwise successful resuscitation. This review examines the mechanisms and therapeutic strategies currently under development to activate the post-conditioning pathways and thereby improve survival and function. Recent findings Post-conditioning utilizes the reperfusion injury salvage kinase (RISK) and survivor activating factor enhancement (SAFE) pathways as common avenues to promote cell survival and function. Ischemic post-conditioning and multiple medications activate these pathways resulting in improved cardiac and neurological function in animal models of cardiac arrest. Summary Detailed knowledge of the RISK and SAFE pathways can be used for further drug development. Human studies are now underway to test some of these strategies, but further clinical trials are necessary to translate these therapies to clinical practice." @default.
- W2009920503 created "2016-06-24" @default.
- W2009920503 creator A5011955638 @default.
- W2009920503 creator A5052318251 @default.
- W2009920503 creator A5057173680 @default.
- W2009920503 creator A5084776953 @default.
- W2009920503 date "2014-06-01" @default.
- W2009920503 modified "2023-09-25" @default.
- W2009920503 title "Post-conditioning to improve cardiopulmonary resuscitation" @default.
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